Trimethoprim

Trimethoprim is an antibiotic commonly used in combination with sulfonamides to treat bacterial infections in animals. It is particularly effective against infections of the urinary tract, respiratory system, gastrointestinal tract, and skin. Read more

Trimethoprim is an antibiotic commonly used in combination with sulfonamides to treat bacterial infections in animals. It is particularly effective against infections of the urinary tract, respiratory system, gastrointestinal tract, and skin.

Essential insights

• Inhibition of dihydrofolate reductase: Trimethoprim works by inhibiting the enzyme dihydrofolate reductase, essential for the synthesis of tetrahydrofolate, a critical component of bacterial DNA synthesis.
• Disruption of bacterial growth: This inhibition prevents bacterial growth and replication, making it bacteriostatic.
• Synergistic effect with sulfonamides: When combined with sulfonamides, a synergistic bactericidal effect is achieved, as both agents target different steps in folate synthesis.