Norodine 24 Injectable Solution is indicated in the treatment of systemic infections caused by or associated with organisms sensitive to the Trimethoprim:Sulfadiazine combination. The spectrum of activity includes both Gram-positive and Gram-negative organisms including:

Actinobacilli

Actinomycae

Bordetella spp

Brucella

Corynebacteria

Escherichia coli

Haemophilus spp

Klebsiella spp

Pasteurella spp

Pneumococci

Proteus

Salmonella spp

Staphylococci

Streptococci

Vibrio

Dose to be administered and administration route

Cattle and Pigs:

The recommended dose rate is 15 mg of active ingredients per kilogram bodyweight (1 ml per 16 kg bodyweight) by intramuscular or slow intravenous injection.

Norodine 24 Injectable Solution may be administered by intravenous injection when rapid blood levels of trimethoprim and Sulfadiazine are required.

Horses:

The recommended dose rate is 15 mg of active ingredients per kilogram bodyweight (1 ml per 16 kg bodyweight), by slow intravenous injection.

Dogs and Cats:

The recommended dose rate is 30 mg of active ingredients per kilogram bodyweight (1 ml per 8 kg bodyweight), by subcutaneous injection only.

The recommended site in dogs is the loose skin at the top of the neck.

A single injection may be sufficient in uncomplicated conditions, but in severe infections it may be repeated daily until 2 days after symptoms resolve, up to a maximum of 5 days.

An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.

Adverse reactions

Anaphylactic shock, potentially fatal, has been observed on rare occasions following administration of potentiated sulphonamide preparations, particularly by the intravenous route. Veterinary surgeons should be mindful of this possibility during the injection process.