Metaxol

1 x 1 l

Solution for use in drinking water

Active substance

Sulfamethoxazole : 100 mg/ml

Trimethoprim : 20 mg/ml

ATC code

QJ01EW11 Sulfamethoxazole and trimethoprim

QJ01EW Comb. of sulfonamides and trimethoprim, incl. derivatives

QJ01E Sulfonamides and trimethoprim

QJ01 Antibacterials for systemic use

QJ Antiinfectives for systemic use

Species

Pigs (fattening pigs) and chickens (broilers).

Indications

Fattening pigs:

Treatment and metaphylaxis of:

- Post-weaning diarrhoea caused by beta-haemolytic K88-positive, K99positive or 987P Escherichia coli strains susceptible to trimethoprimsulfamethoxazole.

- Secondary bacterial infections caused by Pasteurella multocida, Actinobacillus pleuropneumoniae, Streptococcus spp. and Haemophilus parasuis susceptible to trimethoprim-sulfamethoxazole.

Broilers:

Treatment and metaphylaxis of:

- Colibacillosis caused by Escherichia coli susceptible to trimethoprimsulfamethoxazole.

- Coryza caused by Avibacterium paragallinarum susceptible to trimethoprim-sulfamethoxazole.

The presence of the disease in the group/flock must be established before the veterinary medicinal product is used.

Dose to be administered and administration route

Route of administration: in drinking water use.

The veterinary medicinal product can be added directly to the drinking water to prepare a therapeutic solution at the calculated concentration, but can also be used in a concentrated stock solution by adding 200 ml of the veterinary medicinal product per litre of water and diluting this further.

Fattening pigs:

5 mg trimethoprim and 25 mg sulfamethoxazole per kg body weight a day, for 4-7 days. This corresponds to 1 ml of the veterinary medicinal product per 4.0 kg body weight per day. Based on the recommended dose, daily water consumption, and the number and weight of the pigs to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:

Broilers:

7.5 mg trimethoprim and 37.5 mg sulfamethoxazole per kg body weight a day, for 3 days. This corresponds to 1 ml of the veterinary medicinal product per 2.67 kg body weight per day. Based on the recommended dose, daily water consumption, and the number and weight of the birds to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:

To ensure a correct dosage, the body weight and water consumption should be determined as accurately as possible.

The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water and stock solutions should be freshly prepared every 24 hours. During the treatment period animals should not have access to water sources other than the medicated water. However, it should be ensured that animals always have sufficient water available. After the end of the medication period, the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of active substance. The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dosage the concentration of the veterinary medicinal product may need to be adjusted accordingly.

Adverse reactions

Pigs:
Rare (1 to 10 animals / 10,000 animals treated):	Hypersensitivity.
Chickens:
Rare (1 to 10 animals / 10,000 animals treated):	Hypersensitivity. Decreased drinking.

Reporting adverse events is important.

It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for contact details.