Avoid adverse reactions in cats

Cats possess a unique hepatic metabolism, rendering them unable to effectively process certain substances found in veterinary medications. Active ingredients in EU veterinary prescription medicines that cats cannot metabolise include:

1. Permethrin: Commonly used in canine ectoparasiticides, permethrin is highly toxic to cats and can lead to severe neurological symptoms or death upon exposure.
2. Paracetamol (Acetaminophen): While used as an analgesic in humans and occasionally in dogs, paracetamol is extremely toxic to cats, causing methemoglobinemia and hepatic failure.
3. Benzocaine: An anesthetic agent that can induce methemoglobinemia in cats due to their deficient enzymatic pathways.
4. Phenolic compounds: Found in some disinfectants and antiseptics, these compounds are poorly metabolized by cats, leading to potential toxicity.
5. Salicylates (Aspirin): Cats metabolize salicylates slowly, making them susceptible to toxicity even at low doses.
6. Certain Benzodiazepines: Some benzodiazepines can cause idiosyncratic hepatic necrosis in cats.

It is imperative for veterinarians to recognise these metabolic limitations when prescribing medications for feline patients. Ensuring that treatments are specifically formulated for cats and avoiding off-label use of canine or human medications can prevent adverse reactions and safeguard feline health.