Ivermectin
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Ivermectin is an antiparasitic substance widely used for the treatment and prevention of parasitic infections in animals. It is effective against both endoparasites (such as roundworms) and ectoparasites (such as mites and lice).
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Ivermectin is an antiparasitic substance widely used for the treatment and prevention of parasitic infections in animals. It is effective against both endoparasites (such as roundworms) and ectoparasites (such as mites and lice).
Essential insights
- Glutamate-gated chloride channels: Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of parasites, increasing the influx of chloride ions into the cells.
- Paralysis and death: This binding causes hyperpolarization of the cell membrane, leading to paralysis and death of the parasite.
- Selective toxicity: Ivermectin is selectively toxic as mammalian cells lack these glutamate-gated chloride channels, ensuring safety for the host animal when dosed appropriately.
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