Ivermectin

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Ivermectin is an antiparasitic substance widely used for the treatment and prevention of parasitic infections in animals. It is effective against both endoparasites (such as roundworms) and ectoparasites (such as mites and lice). Read more

Ivermectin is an antiparasitic substance widely used for the treatment and prevention of parasitic infections in animals. It is effective against both endoparasites (such as roundworms) and ectoparasites (such as mites and lice).

Essential insights

  • Glutamate-gated chloride channels: Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of parasites, increasing the influx of chloride ions into the cells.
  • Paralysis and death: This binding causes hyperpolarization of the cell membrane, leading to paralysis and death of the parasite.
  • Selective toxicity: Ivermectin is selectively toxic as mammalian cells lack these glutamate-gated chloride channels, ensuring safety for the host animal when dosed appropriately.

Breed-specific drug reactions

Australian Shepherds, Border Collies, Collies, Old English Sheepdogs, Shetland Sheepdogs, and other herding breeds have a breed-specific sensitivity to ivermectin. High doses of ivermectin can lead to severe neurological symptoms in these breeds, including tremors, ataxia, coma, and even death. This sensitivity is due to a genetic mutation (MDR1 gene mutation) that affects the blood-brain barrier, allowing the drug to accumulate in the brain and cause toxicity.

Because of this risk, the use of ivermectin is not recommended in these dog breeds, and safer alternatives should be considered.

Other breeds that can be affected include Whippets, Miniature Schnauzers, Chesapeake Bay Retrievers, Boxers and additional herding breeds like Belgian Tervurens and Swedish Vallhunds.

Sheep

Animec

0,8 mg/ml Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l, 1 x 6 l, 1 x 10 l
Cattle

Animec

5 mg/ml Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 1 x 5 l, 1 x 6 l, 1 x 250 ml, 1 x 500 ml
Pig
Sheep
Cattle

Animec

10 mg/ml Solution for injection (Vial)
1 x 50 ml, 1 x 250 ml, 1 x 500 ml
Horse

Animec

18,7 mg/g Oral paste (Oral.syr.)
20 x 1 pc
Cattle

Animec Super

100 + 10 mg/ml Liquid for injection, solution (Vial)
1 x 50 ml, 1 x 250 ml, 1 x 500 ml
Cattle

Bimamec

5 mg/ml Pour-on, solution (Pour-on)
1 x 5 l, 6 x 2,5 l
Pig
Sheep
Cattle

Bimectin

10 mg/g Solution for injection (Vial)
12 x 250 ml, 6 x 500 ml
Cattle

Bimectin Plus

100 + 10 mg/ml Liquid for injection, solution (Vial)
10 x 250 ml, 6 x 500 ml
Horse

Bimectin vet.

18,7 mg/g Oral paste (Oral.syr.)
10 x 1 pc
Cattle

Closamectin vet.

200 + 5 mg/ml Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 1 x 5 l, 1 x 250 ml, 1 x 500 ml
Cattle

Ecomectin

5 mg/ml Pour-On Solution (Pour-on)
1 x 1 l
Pig

Ecomectin vet.

6 mg/g Premix for medicated feeding (Sachet)
1 x 5 kg, 1 x 333 g
Pig
Sheep
Cattle

Ecomectin vet.

10 mg/ml Liquid for injection, solution (Vial)
1 x 50 ml
Cattle

Enovex

0,5 % w/v Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l
Horse

Equimax Gel

140,3 + 18,7 mg/g Oral gel (Dos.syr.)
1 x 7,49 g, 48 x 7,49 g
Horse

Eqvalan

18,7 mg Oral paste (Oral.syr.)
1 x 1 pc
Horse

Eqvalan Duo

77,5 + 15,5 mg/g Oral paste (Oral.syr.)
1 x 1 pc
Horse

ERAQUELL

18,7 mg/g Oral paste (Dos.syr.)
1 x 7,49 g, 28 x 7,49 g
Sheep

Fasimec Duo

50 + 1 mg/ml Oral Suspension (Flaske)
1 x 2,2 l, 1 x 5 l, 1 x 800 ml
Cattle

Ivomec Classic

5 mg/ml Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 2 x 2,5 l
Sheep
Cattle

Ivomec Classic

10 mg/ml Liquid for injection, solution (Vial)
1 x 200 ml, 1 x 500 ml
Cattle

Ivomec Super

100 + 10 mg/ml Liquid for injection, solution (Vial)
1 x 50 ml, 1 x 200 ml, 1 x 500 ml, 1 x 1000 ml
Horse

Nexmectin

18,7 mg/g Oral paste (Oral.syr.)
20 x 1 pc
Sheep

Noromectin Drench

0,08 % w/v Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l, 2 x 5 l
Horse

Noromectin Equine

18,7 mg/g Oral paste (Oral.syr.)
1 x 1 pc
Pig
Sheep
Cattle

Noromectin Multi

1 % w/v Liquid for injection, solution (Vial)
1 x 50 ml, 1 x 500 ml
Cattle

Noromectin Pour-On

0,5 % w/v Pour-on, solution (Pour-on)
1 x 1 l
Horse

Noropraz vet.

140,3 + 18,7 mg/g Oral paste (Oral.syr.)
1 x 1 pc, 12 x 1 pc
Sheep

Oramec

0,8 mg/ml Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
Pig
Sheep
Cattle

Panomec

10 mg/ml Liquid for injection, solution (Vial)
1 x 50 ml
Cattle

Paramectin

0,5 % w/v Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
Sheep

Paramectin Drench

0,8 mg/ml Oral solution (Flaske)
1 x 2,5 l, 1 x 5 l
Pig
Sheep
Cattle

Paramectin Multi Injection

10 mg/ml Liquid for injection, solution (Vial)
1 x 500 ml
Sheep

Tribamec Duo

50 + 1 mg/ml Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l
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