Noropraz vet.

1 x 1 pc

Oral paste

Active substance

Praziquantel : 140,3 mg/g

Ivermectin : 18,7 mg/g

ATC code

QP54AA51 Ivermectin, comb.

QP54AA Avermectins

QP54A Macrocyclic lactones

QP54 Endectocides

QP Antiparasitic products, insecticides and repellents

Species

Horses.

Indications

For the treatment of mixed cestode and nematode or arthropod infestations, due to adult and immature roundworms, lungworms, bots and tapeworms in horses:

Nematodes:

Large strongyle:

Strongylus vulgaris (adult and arterial larvae),

Strongylus edentatus (adult and L4 tissue larval stages), Strongylus equinus (adult), Tridontophorus spp.(adult).

Small strongyle:

Cyathostomum: Cylicocyclus spp.,

Cylicostephanus spp.,

Cylicodontophorus spp.,

Gyalocephalus spp. (adult and non-inhibited mucosal larvae).

Parascaris: Parascaris equorum (adult and larvae),

Oxyuris: Oxyuris equi (larvae),

Trichostrongylus: Trichostrongylus axei (adult),

Strongyloides: Strongyloides westeri (adult),

Habronema: Habronema spp. (adult),

Onchocerca: Onchocerca spp. microfilariae i.e. cutaneous onchocerciasis, Lungworm: Dietyocaulus arnfieldi (adult and larvae).

Cestodes (Tapeworm):

Anoplocephala perfoliata (adult),

Anoplocephala magna (adult), Paranoplocephala mamillana (adult).

Dipteran insects:

Gasterophilus spp. (larvae).

Dose to be administered and administration route

Oral use.

Single administration.

200 µg of lvermectin and 1.5 mg of Praziquantel per kg of bodyweight corresponding to 1.07 g of paste per 100 kg bodyweight.

To ensure administration of a correct dosage, bodyweight should be determined as accurately as possible and the correct syringe division selected, as underdosing might lead to an increased risk of development of resistance to anthelmintic drugs.

Weight	Dosage	Weight	Dosage
Up to 100 kg	1.070 g	401 – 450 kg	4.815 g
101 – 150 kg	1.605 g	451 – 500 kg	5.350 g
151 – 200 kg	2.140 g	501 – 550 kg	5.885 g
201 – 250 kg	2.675 g	551 – 600 kg	6.420 g
251 – 300 kg	3.210 g	601 – 650 kg	6.955 g
301 – 350 kg	3.745 g	651 – 700 kg	7.490 g
351 – 400 kg	4.280 g

The first division delivers enough paste to treat 50 kg.

Each subsequent syringe division delivers enough paste to treat 50 kg of bodyweight. The syringe should be adjusted to the calculated dosage by setting the ring on the appropriate place on the plunger.

The syringe contains 7.49 g of paste and delivers sufficient paste to treat 700 kg of bodyweight at the recommended dose rate.

Directions for use

Before administration, adjust the syringe to the calculated dosage by setting the ring on the plunger. The paste is administered orally by inserting the nozzle of the syringe through the interdental space and depositing the required amount of the paste on the back of the tongue. The animal's mouth should be free of any food. Immediately after administration, elevate the head of the horse for a few seconds to ensure the dose is swallowed.

The veterinary surgeon should give advice regarding appropriate dosing programmes and stock management to achieve adequate parasite control for both tapeworm and roundworm infestations.

Adverse reactions

Target species: Horses.

Very rare

(<1 animal / 10,000 animals treated, including isolated reports):

Swelling^¹, Anorexia^²,

Itching;

Colic^2,³, Diarrhoea^{2, 3},

Allergic reaction^⁴ (such as Hypersalivation, Tongue oedema, Urticaria, Tachycardia, Congested mucous membranes, Cutaneous oedema)

¹ In horses carrying heavy infection of Onchocerca microfilariae, assumed to be as a result of the destruction of large number of microfilariae.

²Caused by destruction of parasites in cases of very high levels of infestation.

³ Mild and transient.

⁴A veterinarian should be consulted if these signs persist.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.