Milbemycinoxim

Milbemycin oxime is an antiparasitic substance used for the treatment and prevention of parasitic infections in animals. It is primarily used against endoparasites like nematodes and ectoparasites like mites. Read more

Milbemycin oxime is an antiparasitic substance used for the treatment and prevention of parasitic infections in animals. It is primarily used against endoparasites like nematodes and ectoparasites like mites.

Essential insights

• Activation of glutamate-gated ion channels: Milbemycin oxime works by activating glutamate-gated chloride channels in the nervous system of parasites. This leads to increased chloride ion influx, causing paralysis and death of the parasite.
• Selective toxicity: The substance is selectively toxic to parasites, as glutamate-gated chloride channels are unique to them. Host animal cells are minimally affected, ensuring safety for the animal.