Methadone

Methadone is a synthetic opioid used for pain relief and sedation in animals. It is commonly employed to manage moderate to severe pain and as part of presubstance before surgical procedures. Read more

Methadone is a synthetic opioid used for pain relief and sedation in animals. It is commonly employed to manage moderate to severe pain and as part of presubstance before surgical procedures.

Essential insights

• μ-opioid receptor agonist: Methadone binds to and activates μ-opioid receptors in the central nervous system, reducing pain perception.
• NMDA receptor antagonism: Methadone also blocks NMDA receptors, helping to mitigate sensitization and chronic pain.
• Benefits of Methadone: Effective for acute and chronic pain management.
  Reduces the need for other anesthetic agents during surgery.
  Low risk of vomiting compared to other opioids.