Comfortan vet.

To ensure accuracy of dosing, bodyweight should be accurately measured and an appropriately calibrated syringe should be used to administer the product.

Analgesia:

Dogs: 0.5 to 1 mg Methadone HCl per kg bodyweight, SC, IM or IV (corresponding to0.05 to 0.1 ml/kg)

Cats: 0.3 to 0.6 mg Methadone HCl per kg bodyweight, IM (corresponding to 0.03 to 0.06 ml/kg)

As individual response to methadone is varied, and depends partly on the dosage, the age of the patient, individual differences in pain sensitivity and general condition, the optimal dosing regimen should be individually based.

In dogs, onset of action is 1 hour following subcutaneous administration, approximately 15 minutes following intramuscular injection and within 10 minutes following intravenous injection. Duration of effect is approximately 4 hours following intramuscular or intravenous administration.

In cats, onset of action is 15 minutes following administration, and the duration of effect is 4 hours on average.

The animal should be examined regularly to assess if additional analgesia is subsequently required.

Premedication and/or neuroleptanalgesia:

Dogs:

Methadone HCl 0.5-1 mg/kg bodyweight, IV, SC or IM (corresponding to 0.05 to 0.1 ml/kg)

Combinations e.g.:

Methadone HCl 0.5 mg/kg bodyweight, IV (corresponding to 0.05 ml/kg), + e.g. midazolam or diazepam

Induction with propofol, maintenance on isoflurane in oxygen.

Methadone HCl 0.5 mg/kg bodyweight, IV (corresponding to 0.05 ml/kg), + e.g. acepromazine

Induction with thiopentone or propofol to effect, maintenance on isoflurane in oxygen or induction with diazepam and ketamine.

Methadone HCl 0.5 -1.0 mg/kg bodyweight, IV or IM (corresponding to 0.05 to 0.1 ml/kg), + α₂-agonist (e.g. xylazine or medetomidine)

Induction with propofol, maintenance on isoflurane in oxygen in combination with fentanyl or total intravenous anaesthesia (TIVA) protocol: maintenance on propofol in combination with fentanyl.

TIVA protocol: induction propofol, to effect. Maintenance on propofol and remifentanil. Chemical-physical compatibility has only been demonstrated for dilutions 1:5 with the following solutions for infusion: sodium chloride 0.9%, Ringer’s solution, and glucose 5%.

Cats:

Methadone HCl 0.3-0.6 mg/kg bodyweight, IM (corresponding to 0.03 to 0.06 ml/kg) Induction with benzodiazepine (e.g. midazolam) and dissociative (e.g. ketamine). With a tranquiliser (e.g. acepromazine) and NSAID (meloxicam) or sedative ( e.g. α₂agonist)

Induction with propofol, maintenance on isoflurane in oxygen.

Doses are dependent on the desired degree of analgesia and sedation, desired duration of effect and the concurrent use of other analgesics and anaesthetics.

When used in combination with other products, lower dosages can be used.

For safe use with other veterinary medicinal products, reference must be made to the relevant product literature.