Lotilaner

Lotilaner is an antiparasitic substance used to treat and prevent parasitic infections in animals. Lotilaner is primarily utilized for the control of ectoparasites such as fleas and ticks in companion animals like dogs and cats. Read more

Lotilaner is an antiparasitic substance used to treat and prevent parasitic infections in animals. Lotilaner is primarily utilized for the control of ectoparasites such as fleas and ticks in companion animals like dogs and cats.

Essential insights

• Inhibition of GABA receptors: Lotilaner works by inhibiting gamma-aminobutyric acid (GABA)-dependent chloride channels in the nervous system of parasites. This blocks normal signal transmission in the parasite's nervous system.
• Paralysis and death: This inhibition causes overstimulation of the parasite's nerve cells, resulting in paralysis and eventual death.
• Selective toxicity: Lotilaner is selectively toxic to parasites due to its higher affinity for their GABA receptors compared to those in mammalian nervous systems, ensuring minimal impact on the host animal.