Afoxolaner

Afoxolaner is an antiparasitic substance, primarily for treating fleas and ticks in dogs. It belongs to a class of drugs known as isoxazolines. Read more

Afoxolaner is an antiparasitic substance, primarily for treating fleas and ticks in dogs. It belongs to a class of drugs known as isoxazolines.

Essential insights

• Target: Afoxolaner targets the central nervous system of parasites by inhibiting specific neurotransmitter pathways.
• Inhibition of GABA and glutamate receptors: It blocks gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels in the nervous systems of parasites. These channels are crucial for transmitting signals in nerve cells.
• Neurotoxic effect: The inhibition of these channels leads to uncontrolled nerve excitation, paralysis, and eventually death of the parasites.