Vetmulin

1 x 5 kg

Premix for medicated feeding

Active substance

Tiamulin (Tiamulin hydrogenfumarate) : 100 mg/g

ATC code

QJ01XQ01 Tiamulin

QJ01XQ Pleuromutilins

QJ01X Other antibacterials

QJ01 Antibacterials for systemic use

QJ Antiinfectives for systemic use

Species

Pigs

Chickens (broiler, replacement pullet, layer/breeder)

Turkeys (poult (grower) and breeder)

Rabbits

Indications

Pigs

For the treatment and metaphylaxis, when the disease is present in the group, of swine dysentery caused by Brachyspira hyodysenteriae susceptible to tiamulin. The presence of the disease in the group must be established before the product is used.

For the treatment of colitis caused by Brachyspira pilosicoli

For the treatment of ileitis caused by Lawsonia intracellularis

For the treatment of enzootic pneumonia caused by Mycoplasma hyopneumoniae Chickens

For the treatment and metaphylaxis, when the disease is present at herd level, of chronic respiratory disease (CRD) and airsacculitis caused by Mycoplasma gallisepticum and Mycoplasma synoviae susceptible to tiamulin. The presence of the disease in the herd should be established before use.

Turkeys

For the treatment and metaphylaxis, when the disease is present at herd level, of infectious sinusitis and airsacculitis caused by Mycoplasma gallisepticum, Mycoplasma meleagridis and Mycoplasma synoviae susceptible to tiamulin. The presence of the disease in the herd should be established before use.

Rabbits

For the treatment and metaphylaxis, when the disease is present at herd level, of epizootic rabbit enterocolitis (ERE) caused by pathogens susceptible to tiamulin. The presence of the disease in the herd should be established before use.

Dose to be administered and administration route

For oral administration only after incorporation in medicated feed.

The uptake of medicated feed depends on the clinical condition of the animals. In order to obtain the correct dosage the concentration of tiamulin should be adjusted using the following formula:

To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing.

Pigs

Treatment and metaphylaxis of Swine Disentery caused B. hyodysenteriae, treatment of Porcine Colonic Spirochaetosis (colitis) caused by B. pilosicoli.

Dosage: 5 – 10 mg tiamulin hydrogen fumarate (equivalent to 4.05 – 8.1 mg tiamulin base) / kg bodyweight daily administered for 7 to 10 consecutive days. The dosage will normally be achieved by an inclusion level of 100 – 200 ppm tiamulin hydrogen fumarate in the finished feed providing that feed intake is unaffected.

Treatment of Porcine Proliferative Enteropathy (ileitis) caused by L. intracellularis.

Dosage: 7.5 mg tiamulin hydrogen fumarate (equivalent to 6.075 mg tiamulin base) / kg bodyweight daily administered for 10-14 consecutive days. The dosage will normally be achieved by an inclusion level of 150 ppm tiamulin hydrogen fumarate in the finished feed providing that feed intake is unaffected.

Treatment of Enzootic Pneumonia caused by M. hyopneumoniae.

Dosage: 5.0 – 10.0 mg tiamulin hydrogen fumarate (equivalent to 4.05 – 8.1 mg tiamulin base) / kg bodyweight daily administered for 7 to 10 consecutive days. The dosage will normally be achieved by an inclusion level of 100 - 200 ppm tiamulin hydrogen fumarate in the finished feed, providing that feed intake is unaffected.

Secondary infection by organisms such as Pasteurella multocida and Actinobacillus pleuropneumoniae may complicate enzootic pneumonia and require specific medication.

Chickens (broiler, replacement pullet, laying and breeding hens)

Treatment and metaphylaxis of chronic respiratory disease (CRD) caused by M. gallisepticum and airsacculitis and infectious synovitis caused by M. synoviae.

Dosage - Treatment and metaphylaxis: 25 mg tiamulin hydrogen fumarate (equivalent to 20.25 mg tiamulin base) / kg body weight daily administered for the period of 3 to 5 consecutive days. This is normally achieved by an inclusion level of 250 - 500 ppm tiamulin hydrogen fumarate in the finished feed provided that feed intake is unaffected.

Turkeys (young poults, breeding turkeys)

Treatment and metaphylaxis of infectious sinusitis and airsacculitis caused by M. gallisepticum, M. synoviae and M. meleagridis.

Dosage - Treatment and metaphylaxis: 40 mg tiamulin hydrogen fumarate (equivalent to 32.4 mg tiamulin base) / kg body weight daily administered for the period of 3 to 5 consecutive days. This is normally achieved by an inclusion level of 250 - 500 ppm tiamulin hydrogen fumarate in finished feed provided that feed intake is unaffected.

Metaphylaxis with tiamulin should only be initiated after confirmed infection with M. gallisepticum, M. synoviae and M. meleagridis and then as an aid in the metaphylaxis strategy to reduce the clinical signs and mortality from respiratory disease in flocks, where infection in ovum is likely because the disease is known to exist in the parent generation. The metaphylaxis strategy should include efforts to eliminate the infection from the parent generation.

Rabbits

Treatment of Epizootic Rabbit Enterocolitis (ERE) and metaphylaxis of ERE in farms with clinical signs of ERE in the previous fattening cycle as part of a programme including measures aiming to eradicate or control the infection in the farm.

Dosage: 3 mg tiamulin hydrogen fumarate (equivalent to 2.43 mg tiamulin base) / kg body weight daily. The dosage will normally be achieved by an inclusion level of 40 ppm tiamulin hydrogen fumarate in the finished feed provided that feed intake is unaffected. Treatment should be administered until 2 - 3 days after clinical signs have resolved. Metaphylaxis should be administered during 3 – 4 weeks from the first week after weaning.

Medicated feed may be pelleted using a pre-conditioning step for 5 minutes at a temperature not exceeding 75°C.

Adverse reactions

In rare cases, hypersensitivity to tiamulin following oral administration to pigs is reported in terms of acute dermatitis with cutaneous erythema and intense pruritus. The adverse reactions are usually mild and transient but in very rare cases may be serious. If these typical side effects occur, stop treatment immediately and clean animals and pens with water. Normally, affected animals recover quickly.

Symptomatic treatment such as electrolyte therapy and an anti-inflammatory therapy may be useful.