area should be cleaned mechanically or by irrigation taking care to avoid further damage to the skin. Any excess exudate, hair or debris should be carefully removed prior to the application of the ear drops. Animal owners should only do this on the direction of the prescribing veterinary surgeon.

Shake the bottle well before use.

Instil 5-10 drops into the ear according to the size of the animal and ear canal twice daily.

Without allowing the animal to shake its head, very gently massage the ear canal after administration holding the pinna in an upright position to ensure penetration of the drops into the ear.

Where ear mite infection is present, consideration should be given to treating both ears, even if infection is apparent in only one. Treatment should continue for at least 3 weeks to ensure that successive generations of ear mites are killed. Animals that are in contact should also be treated.

Where treatment is for a period longer than 7 days regular clinical reevaluation should be carried out.

Where Gram-negative infections are involved, the use of the veterinary medicinal product should be based on bacterial sensitivity testing. In cases where the treatment period is prolonged, in vitro sensitivity should be reevaluated.

Adverse reactions

On very rare occasions and primarily in geriatric animals, use of auricular preparations may be associated with hearing impairment which may be either transient or prolonged.

Allergy or hypersensitivity reactions to the active substances or the excipient might occur.

Anti-inflammatory corticosteroids such as Prednisolone can exert a wide range of side effects. Dosage in medium to long term use should therefore generally be kept to the minimum.

During therapy effective doses suppress the hypothalamic-pituitreal adrenal axis. Following cessation of treatment symptoms of adrenal insufficiency can arise and this may render the animal unable to deal adequately with stressful situations.

Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to, or exacerbate existing infections.