Tialin

In drinking water use.

The veterinary medicinal product should be administered using suitably calibrated equipment.

Guidance for preparing veterinary medicinal product solutions:

When medicating large volumes of water, prepare a concentrated solution first and then dilute to the required final concentration.

The veterinary medicinal product is soluble and stable from low concentration up to maximum concentration of the veterinary medicinal product of 500 ml/L (1:2 dilution) in water of at least 4° C.

Fresh solutions of tiamulin-medicated drinking water should be made up each day. Any medicated drinking water remaining from the previous day should be discarded.

To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing. The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dosage, the concentration of tiamulin has to be adjusted accordingly.

Make sure the animals do not have access to non-medicated water during the period when the medicated water is given.

After the end of the medication period the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance.

In order to avoid interactions between the ionophores and tiamulin, the veterinarian and farmer should check that the feed label does not state that it contains salinomycin, monensin or narasin.

For chickens and turkeys, in order to avoid interactions between the incompatible ionophores monensin, narasin or salinomycin and tiamulin, the feed mill supplying the birds’ feed should be notified that tiamulin will be used and that these anticoccidials should not be included in the feed or contaminate the feed.

The feed should be tested for the ionophores prior to use if there is any suspicion that contamination of the feed might occur.

If an interaction does occur, stop tiamulin medication immediately and replace with fresh drinking water. Remove contaminated feed as soon as possible and replace with feed not containing the tiamulin-incompatible ionophores.

Based on the recommended dose and the number and weight of animals to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:

 
Pigs:

1. For the treatment of Swine Dysentery caused by Brachyspira hyodysenteriae.

The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg body weight administered daily in the drinking water of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or the duration of the disease.

2. For the treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira pilosicoli.

The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg body weight administered daily in the drinking water of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or the duration of the disease.

3. For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia intracellularis.

The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg body weight administered daily in the drinking water of pigs for 5 consecutive days.

4. For the treatment and metaphylaxis of Enzootic Pneumonia caused by Mycoplasma hyopneumoniae, including infections complicated by Pasteurella multocida susceptible to tiamulin.

The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 0.16 ml solution)/kg body weight administered daily for 5 consecutive days.

5. For the treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae susceptible to tiamulin.

The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 0.16 ml solution)/kg body weight administered daily for 5 consecutive days.

Chickens:

For the treatment and metaphylaxis of Chronic Respiratory Disease caused by Mycoplasma gallisepticum and Airsacculitis and Infectious Synovitis caused by Mycoplasma synoviae.

The dosage is 25 mg tiamulin hydrogen fumarate (equivalent to 0.2 ml solution)/kg body weight administered daily for the period of 3 to 5 consecutive days.

Turkeys:

For the treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis.

The dosage is 40 mg tiamulin hydrogen fumarate (equivalent to 0.32 ml solution)/kg body weight administered daily for the period of 3 to 5 consecutive days.