Nuflor
Active substance
ATC code
Species
Cattle and sheep.
Indications
Cattle:
Diseases caused by florfenicol susceptible bacteria.
Metaphylactic and therapeutic treatment of respiratory tract infections in cattle due to Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. The presence of the disease in the herd should be established before metaphylactic treatment.
Sheep:
Treatment of ovine respiratory tract infections due to Mannheimia haemolytica and Pasteurella multocida susceptible to florfenicol.
Dose to be administered and administration route
Swab septum before removing each dose. Use a dry sterile needle and syringe.
To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing.
The vials should not be broached more than 20 times. User should therefore select the most appropriate vial size according to the target species to be treated.
When treating groups of animals at the same time, use of a draw-off needle in the vial stopper is recommended to avoid excess stopper broaching. The draw-off needle should be removed after treatment.
For treatment
Cattle:
Intramuscular use: 20 mg/kg bodyweight (1 ml/15 kg) to be administered twice 48 hours apart using a 16 gauge needle.
Subcutaneous use: 40 mg/kg bodyweight (2 ml/15 kg) to be administered once only using a 16 gauge needle. The dose volume given at any one injection site should not exceed 10 ml.
The injection should only be given in the neck.
Sheep:
Intramuscular use: 20 mg florfenicol/kg bodyweight (1 ml/15 kg) to be administered daily for three consecutive days. The volume administered per injection site should not exceed 4 ml.
Pharmacokinetic studies showed that mean plasma concentrations remain above MIC90 (1 μg/ml) for up to 18 hours after administration of the product at the recommended treatment dose. The pre-clinical data supported the recommended treatment interval (24 hours) for target pathogens with MIC up to 1 μg/ml.
For metaphylaxis
Cattle:
Subcutaneous use: 40 mg/kg bodyweight (2 ml/15 kg) to be administered once only using a 16 gauge needle. The dose volume given at any one injection site should not exceed 10 ml.
The injection should only be given in the neck.
Adverse reactions
Cattle:
A decrease in food consumption and transient softening of the faeces may occur during the treatment period. The treated animals recover quickly and completely upon termination of treatment.
Intramuscular and subcutaneous administration may cause inflammatory lesions at the injection site which may persist for 14 days.
In very rare cases, anaphylactic shock has been reported in cattle.
Sheep:
A decrease in food consumption may occur during the treatment period. The treated animals recover quickly and completely upon termination of treatment.
Intramuscular administration may cause inflammatory lesions at the injection site which may persist up to 28 days. Typically, these are mild and transient.