Denagard vet.

1 x 1 l

Oral solution

Active substance

Tiamulin (Tiamulin hydrogenfumarate) : 125 mg/ml

ATC code

QJ01XQ01 Tiamulin

QJ01XQ Pleuromutilins

QJ01X Other antibacterials

QJ01 Antibacterials for systemic use

QJ Antiinfectives for systemic use

Species

Pigs, chickens and turkeys

Indications

Pigs:

For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp.

Chickens:

For the reduction in the severity of disease caused by mycoplasmas.

Turkeys:

For the reduction in the severity of disease caused by mycoplasmas.

Dose to be administered and administration route

Pigs:

The dosage is 8.8 mg of the active substance per kg bodyweight daily, (equivalent to 10 ml solution per 142 kg bodyweight) administered in the drinking water of pigs for 3 to 5 days, depending on the severity of the infection and/or the duration of the disease.

The contents of each 250 ml bottle will treat 46 pigs of 25 kg bodyweight for 3 days or 28 pigs of 25 kg bodyweight for 5 days.

The contents of each 1 litre bottle will treat 188 pigs of 25 kg bodyweight for 3 days or 114 pigs of 25 kg bodyweight for 5 days.

To ensure an intake of 8.8 mg/kg daily, the product may be administered in one of two ways:

i) Administer in approximately one half of the daily water requirements, to ensure consumption of the correct dose. Unmedicated water should be provided each day after the medicated water has been consumed. The dosage rate, calculated on a liveweight basis, is equivalent to 10 ml solution per 142 kg bodyweight.

ii) Administer continuously at a level of 60 ppm of active substance in the drinking water, as the only source of drinking water. The daily requirement should be added to the drinking water at the rate of 9.6 ml Solution per 20 litres (4.5 gallons) of water.

Where a water medicator is used the appropriate stock solution should always be made up according to the maker's instructions.

If there is no response to treatment within 5 days, the diagnosis should be reestablished.

Chickens:

The dosage for chickens is 25 mg of active substance per kg bodyweight (equivalent to 100 ml solution per 500 kg bodyweight). Tiamulin should be administered at 0.025% in drinking water (2 ml product per litre of water) for 3 – 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird.

Day old chick:	125 – 150 mg/kg bodyweight
4 week old broiler:	30 – 50 mg/kg bodyweight
10 week old pullet:	30 – 45 mg/kg bodyweight
Layer:	25 mg/kg bodyweight

Turkeys:

The dosage for turkeys is 25 mg of active substance per kg bodyweight (equivalent to 100 ml solution per 500 kg bodyweight). Tiamulin should be administered at 0.025% in drinking water (2 ml product per litre of water) for 5 days and will provide approximately the following daily dosage of tiamulin depending on the age of the bird.

1 week old poult: 70 mg/kg bodyweight

4 week old poult: 50 mg/kg bodyweight

8 week old poult: 20 – 30 mg/kg bodyweight 20 week old poult: 25 mg/kg bodyweight

Monitor water intake at frequent intervals during medication.

Fresh solutions of tiamulin-medicated drinking water should be made up each day.

Adverse reactions

On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate.

Water intake may be depressed during the administration of tiamulin to birds. It appears to be concentration dependant with 0.025% tiamulin reducing intake by approximately 15%. It does not appear to have any adverse effect on overall performance of the birds or efficacy of the product.