Vectra 3D (25 - 40 kg)

3 x 1 pc

Spot-on, solution

Active substance

Permethrin : 1.865 mg/pipette

Dinotefuran : 256 mg/pipette

Pyriproxifen : 22,7 mg/pipette

ATC code

QP53AC54 Permethrin, comb.

QP53AC Pyrethrines and pyrethroids

QP53A Ectoparaciticides for topical use, incl. insecticides

QP53 Ectoparaciticides, insecticides and repellents

QP Antiparasitic products, insecticides and repellents

Species

Dogs.

Indications

Fleas:

Treatment and prevention of flea infestation (Ctenocephalides felis and Ctenocephalides canis). The treatment prevents flea infestation for one month. It also prevents multiplication of fleas for two months after application by inhibiting egg hatching (ovicidal activity) and by inhibiting the emergence of adults from eggs laid by adult fleas (larvicidal activity).

Ticks:

The veterinary medicinal product has persistent acaricidal and repellent efficacy against tick infestations (Rhipicephalus sanguineus and Ixodes ricinus for one month, and Dermacentor reticulatus for up to three weeks).

If ticks are present when the veterinary medicinal product is applied, the ticks may not all be killed within the first 48 hours, but they may be killed within a week. To remove ticks, it is recommended to use an appropriate tick removal device.

Sand flies, mosquitoes and stable flies:

The treatment provides persistent repellent (anti-feeding) activity. It prevents biting from sand flies (Phlebotomus perniciosus), mosquitoes (Culex pipiens, Aedes aegypti) and from stable flies (Stomoxys calcitrans) for one month post-application. The treatment also provides persistent insecticidal activity for one month against mosquitoes (Aedes aegypti) and stable flies (Stomoxys calcitrans).

Dose to be administered and administration route

Spot-on use.

One applicator per dog.

Dosage:

The minimum recommended dose is 6.4 mg dinotefuran/kg body weight, 0.6 mg pyriproxyfen/kg body weight and 46.6 mg permethrin/kg body weight, equivalent to 0.12 ml of the veterinary medicinal product per kg body weight.

The following table shows the size of spot-on applicator to be used according to the weight of the dog:

Weight of dog (kg)	Colour of applicator cap	Volume (ml)	Applicator to be used
1.5-4 kg	Yellow	0.8	1 applicator of	Vectra 3D for dogs 1.5-4 kg
> 4-10 kg	Teal	1.6		Vectra 3D for dogs > 4-10 kg
> 10-25 kg	Blue	3.6		Vectra 3D for dogs > 10-25 kg
> 25-40 kg	Purple	4.7		Vectra 3D for dogs > 25-40 kg
> 40 kg	Red	8.0		Vectra 3D for dogs > 40 kg

Care should be taken to apply the veterinary medicinal product only onto intact (undamaged) dog's skin.

How to apply:

Remove the spot-on applicator from the pack.

Step 1: Hold the applicator upright, placing fingers below the larger disk as shown.

Step 2: With the other hand, press downwards on the smaller disk until the 2 disks meet evenly. This will pierce the seal.

Step 3: The dog should be standing or in a comfortable position for easy application. Part the hair until the skin is visible. Apply the veterinary medicinal product (as directed in step 4 below) slowly with the tip of the applicator on the skin.

Step 4

Use according to 4a or 4b recommendation:

4a recommendation: Gently squeeze the applicator and apply the veterinary medicinal product to the skin along the dog's back, beginning between the shoulder blades, in the number of spots and order shown in the diagrams below and squeezing until the applicator is empty. Avoid superficial application to the dog’s hair. The number of application spots will depend on the body weight of the dog.

Dogs from 1.5 to 4 kg body weight 1 yellow pipette per dog

Dogs over 4 kg and up to 10 kg body weight 1 teal pipette per dog to be split in 2 spots

Dogs over 10 kg and up to 40 kg body weight

1 blue or purple pipette per dog to be split in 3 spots

Dogs over 40 kg body weight

1 red pipette per dog to be split in 4 spots

4b recommendation: Regardless of the dog’s body weight, using the applicator tip, part the hair at the base of the tail and begin applying the veterinary medicinal product directly onto the skin in a continuous line from the base of the tail along the centre of the back all the way up to the shoulder blades, as shown in the diagram, squeezing the applicator until it is empty.

Treatment schedule:

Following a single administration, the veterinary medicinal product will prevent infestation for one month. The treatment can be repeated once a month.

Adverse reactions

Dogs:

Rare

(1 to 10 animals / 10,000 animals treated):

Application site reaction¹ (e.g. Erythema, Pruritus)

Discomfort^1,2

Behavioural disorder (e.g. Hyperactivity, Vocalisation,

Anxiety)

Neurological disorder (e.g. Muscle tremor)

Systemic disorder (e.g. Lethargy, Anorexia)

Very rare

(<1 animal / 10,000 animals treated, including isolated reports):

Application site reaction³ (e.g. Hair change (wet appearance, spiking), Residue)

Digestive tract disorder (e.g. Vomiting, Diarrhoea) Ataxia (e.g. Unsteady movement)

Convulsion

¹ Mild and transient. If signs persist or worsen, veterinary advice should be sought.

² At the application site.

³ Transient, these signs are usually not noticeable after 48 hours.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.