Trilostane

Trilostan is a substance used to treat hormonal disorders in animals. Trilostan is primarily used for managing hyperadrenocorticism (Cushing’s syndrome) in dogs and occasionally in cats. Read more

Trilostan is a substance used to treat hormonal disorders in animals. Trilostan is primarily used for managing hyperadrenocorticism (Cushing’s syndrome) in dogs and occasionally in cats.

Essential insights

• Inhibition of corticosteroid synthesis: Trilostan works by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, essential for the production of corticosteroids like cortisol in the adrenal cortex.
• Reduction of cortisol production: By suppressing cortisol synthesis, trilostan alleviates the symptoms associated with excessive hormone production.
• Selective toxicity: Trilostan specifically targets the adrenal cortex without interfering with normal physiological processes in the host animal when dosed appropriately.