Spironolactone
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Spironolactone is a diuretic and aldosterone antagonist used to treat heart and kidney conditions in animals. It is commonly prescribed for dogs and cats suffering from congestive heart failure or proteinuria due to chronic kidney disease.
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Spironolactone is a diuretic and aldosterone antagonist used to treat heart and kidney conditions in animals. It is commonly prescribed for dogs and cats suffering from congestive heart failure or proteinuria due to chronic kidney disease.
Essential insights
- Inhibition of aldosterone receptors: Spironolactone blocks the binding of aldosterone to its receptors in the renal tubules. This reduces sodium and water retention while promoting potassium excretion.
- Reduction of fluid buildup: By decreasing aldosterone activity, spironolactone minimizes fluid accumulation in tissues and lungs, improving circulation and respiration.
- Anti-fibrotic effects: Spironolactone can inhibit tissue fibrosis in the heart and kidneys, potentially enhancing organ function.
- Selective Toxicity:
Spironolactone specifically targets aldosterone receptors predominantly active in animals with heart or kidney diseases, with minimal effects on other hormones, making it relatively safe when dosed correctly.
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