Cardalis chewable tablets should be administered to the dog once a day at a dosage of 0.25 mg/kg bodyweight (bw) benazepril hydrochloride (HCl) and 2 mg/kg bodyweight spironolactone, according to the following dosage table.

The tablets should be administered with food, either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself. The tablets contain beef flavouring to improve palatability, and in a field study conducted in dogs with chronic degenerative valvular disease the tablets were voluntarily and fully consumed 92% of the time when offered either with or without food.

Bodyweight (kg) of dog	Strength and number of tablets to be administered:
	Cardalis 2.5 mg/20 mg chewable tablets	Cardalis 5 mg/40 mg chewable tablets	Cardalis 10 mg/80 mg chewable tablets
2.5 - 5	½
5 - 10	1
10 - 20		1
20 - 40			1
40 - 60			1 + ½
60 - 80			2

Adverse reactions

Vomiting, diarrhoea, pruritus, lethargy, anorexia, ataxia, incoordination or signs of fatigue have been reported very rarely.

In dogs with chronic kidney disease, benazepril may increase plasma creatinine concentrations at the start of therapy very rarely. A moderate increase in plasma creatinine concentrations following administration of ACE inhibitors is compatible with the reduction in glomerular hypertension induced by these agents and is therefore not necessarily a reason to stop therapy in the absence of other signs.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals treated displaying adverse reaction(s))- common

(more

than 1 but less than 10 animals treated in 100 animals treated)

- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)

- rare (more than 1 but less than 10 animals in 10,000 animals treated)

- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).