Pregabalin

Pregabalin is an anticonvulsant and analgesic used for treating neuropathic pain and seizures in animals. It is often combined with other drugs to enhance treatment efficacy. Read more

Pregabalin is an anticonvulsant and analgesic used for treating neuropathic pain and seizures in animals. It is often combined with other drugs to enhance treatment efficacy.

Essential insights

• Calcium channel inhibition: Pregabalin binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P.
• Pain relief: By inhibiting neurotransmitter release, it decreases the transmission of pain signals, reducing the animal’s perception of pain.
• Seizure control: Pregabalin suppresses neuronal hyperexcitability, helping to manage epileptic seizures.
• Selective Toxicity: Pregabalin primarily affects nerve cells involved in pain and seizures, with limited impact on normal neural function, minimizing side effects.