Posaconazole

Posaconazole is a broad-spectrum antifungal substance used for treating severe fungal infections in animals. It is primarily administered systemically to address infections such as Aspergillosis, Candida infections, and other invasive mycoses. Read more

Posaconazole is a broad-spectrum antifungal substance used for treating severe fungal infections in animals. It is primarily administered systemically to address infections such as Aspergillosis, Candida infections, and other invasive mycoses.

Essential insights

• Inhibition of Ergosterol Synthesis: Posaconazole targets the enzyme lanosterol 14α-demethylase, disrupting the production of ergosterol, a vital component of fungal cell membranes.
• Disruption of Cell Membrane: The lack of ergosterol leads to structural and functional defects in the fungal cell membrane, causing cell death.
• Selective Toxicity: Posaconazole is selectively toxic to fungal cells due to their reliance on ergosterol, whereas animal cells use cholesterol, ensuring minimal side effects for the host.