Monepantel

Monepantel is an antiparasitic substance used for the treatment of parasitic infections in animals, primarily livestock such as sheep and cattle. It is particularly effective against resistant gastrointestinal nematodes. Read more

Monepantel is an antiparasitic substance used for the treatment of parasitic infections in animals, primarily livestock such as sheep and cattle. It is particularly effective against resistant gastrointestinal nematodes.

Essential insights

• Activation of AAD Receptors: Monepantel works by binding to specific AAD (acetylcholine receptor subunits) receptors in nematodes, which are not found in other animal species. This disrupts the parasite’s neuromuscular function.
• Paralysis and Death: This binding leads to loss of mobility and the ability to absorb nutrients, resulting in the parasite’s death.
• Selective Toxicity: Monepantel is selectively toxic to nematodes because these receptors are absent in mammals, making it safe for the host animal.