Miconazole

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Miconazole is an antifungal substance used to treat fungal infections in animals. It is commonly applied topically to manage conditions such as ringworm, yeast infections, and other skin infections in various animal species. Read more

Miconazole is an antifungal substance used to treat fungal infections in animals. It is commonly applied topically to manage conditions such as ringworm, yeast infections, and other skin infections in various animal species.

Essential insights

  • Inhibition of Ergosterol Synthesis: Miconazole works by inhibiting the synthesis of ergosterol, targeting the enzyme lanosterol 14α-demethylase, which is essential for fungal cell membrane structure.
  • Disruption of the Cell Membrane: By disrupting ergosterol synthesis, miconazole compromises the integrity of the fungal cell membrane, causing increased permeability and eventual cell death.
  • Selective Toxicity: Miconazole is selectively toxic to fungal cells due to its specific action on ergosterol, while animal cells utilize cholesterol in their membranes, reducing side effects in the host.
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