Ketoconazole

Ketoconazole is an antifungal substance used to treat fungal infections in animals. It is applied topically or systemically to address conditions like ringworm, yeast infections, and systemic mycoses in various animal species. Read more

Ketoconazole is an antifungal substance used to treat fungal infections in animals. It is applied topically or systemically to address conditions like ringworm, yeast infections, and systemic mycoses in various animal species.

Essential insights

• Inhibition of Ergosterol Synthesis: Ketoconazole works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It targets the enzyme lanosterol 14α-demethylase, disrupting membrane structure.
• Disruption of Cell Membrane: By inhibiting ergosterol synthesis, the integrity of fungal cell membranes is compromised, leading to leakage of cellular contents and cell death.
• Selective Toxicity: Ketoconazole is selectively toxic to fungal cells, which rely on ergosterol, while host cells use cholesterol, thereby reducing side effects.