Itraconazole

Itraconazole is an antifungal substance used to treat various fungal infections in animals. It is commonly administered systemically and is effective against infections such as aspergillosis, candidiasis, and dermatophytosis in various species. Read more

Itraconazole is an antifungal substance used to treat various fungal infections in animals. It is commonly administered systemically and is effective against infections such as aspergillosis, candidiasis, and dermatophytosis in various species.

Essential insights

• Inhibition of Ergosterol Synthesis: Itraconazole inhibits the synthesis of ergosterol, an essential component of fungal cell membranes. It targets the enzyme lanosterol 14α-demethylase, which converts lanosterol to ergosterol.
• Disruption of the Cell Membrane: By inhibiting ergosterol synthesis, itraconazole disrupts the membrane structure and function of fungal cells, leading to cell death.
• Selective Toxicity: Itraconazole is selectively toxic to fungal cells because animal cells use cholesterol in their membranes, minimizing side effects in the host.