Esafoxolaner

Esafoxolaner is an antiparasitic substance used for the treatment and prevention of parasitic infections in animals. Esafoxolaner is primarily used to control fleas and ticks in dogs and cats. Read more

Esafoxolaner is an antiparasitic substance used for the treatment and prevention of parasitic infections in animals. Esafoxolaner is primarily used to control fleas and ticks in dogs and cats.

Essential insights

• Inhibition of GABA-gated ion channels: Esafoxolaner works by inhibiting gamma-aminobutyric acid (GABA)-gated chloride channels in the parasite's nervous system.
• Neuromuscular blockade: This results in overstimulation of the parasite's nervous system, leading to paralysis and death.
• Selective toxicity: Esafoxolaner is selectively toxic to insects and ticks, as their GABA receptors differ from those in mammals. This minimizes the risk of side effects in the host animal.