Doramectin

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Doramectin is an antiparasitic substance used to treat and control parasitic infections in animals. It is primarily used in cattle, sheep, and swine but is also effective in other animal species. Read more

Doramectin is an antiparasitic substance used to treat and control parasitic infections in animals. It is primarily used in cattle, sheep, and swine but is also effective in other animal species.

Essential insights

  • Stimulation of glutamate-gated ion channels: Doramectin binds to glutamate-gated ion channels in the parasite's nervous system, increasing chloride ion permeability.
  • Neuromuscular blockade: This leads to neuromuscular paralysis, ultimately resulting in the death of the parasite.
  • Selective toxicity: Doramectin is selectively toxic to parasites as glutamate-gated ion channels are not present in the central nervous system of the host animal.

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