Closantel

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Closantel is an anthelmintic substance used for the treatment of various parasitic infections, particularly those caused by liver flukes and other external parasites in livestock. Read more

Closantel is an anthelmintic substance used for the treatment of various parasitic infections, particularly those caused by liver flukes and other external parasites in livestock.

Essential insights

  • Inhibition of energy metabolism: Closantel works by disrupting the energy metabolism of parasites. It specifically inhibits the oxidative phosphorylation process in the mitochondria of the parasites, leading to a significant reduction in ATP (adenosine triphosphate) production. This energy deprivation results in the death of the parasites.
  • Selective toxicity: Closantel is selectively toxic to parasites while having minimal effects on the host animals. Its action is primarily targeted at the metabolic processes of flukes and some other helminths, making it effective against liver flukes (Fasciola spp.), stomach worms, and some ectoparasites.
  • Impact on parasite movement and attachment: Closantel may also affect the ability of parasites to attach to the host’s tissues and impair their mobility, contributing further to their elimination from the host.
Cattle

Closamectin vet.

200 + 5 mg/ml Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 1 x 5 l, 1 x 250 ml, 1 x 500 ml
Sheep

Flukiver

50 mg/ml Oral Suspension (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
Sheep

Solantel

50 mg/ml Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
Cattle

Solantel

200 mg/ml Pour-on, solution (Pour-on)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
Sheep

Supaverm

75 + 50 mg/ml Oral solution (Flaske)
1 x 1 l, 1 x 2,5 l, 1 x 5 l
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