Clorsulon

Clorsulon is an antihelmintic substance used primarily for the treatment of liver fluke infections in cattle. Clorsulon is used in combination with other drugs, such as ivermectin, for comprehensive control of parasitic infections. Read more

Clorsulon is an antihelmintic substance used primarily for the treatment of liver fluke infections in cattle. Clorsulon is used in combination with other drugs, such as ivermectin, for comprehensive control of parasitic infections.

Essential insights

• Inhibition of glycolysis: Clorsulon works by interfering with the glycolytic pathway in liver flukes (Fasciola spp.). It inhibits key enzymes involved in glucose metabolism, leading to a decrease in the energy supply for the flukes.
• Energy Depletion: By blocking glycolysis, clorsulon causes a depletion of ATP (adenosine triphosphate) within the parasites. This energy depletion results in the death of the flukes, as they are unable to maintain essential metabolic processes.
• Selective Toxicity: Clorsulon specifically targets the metabolic processes of liver flukes while having minimal impact on the host animal. This selective action makes it effective against these parasites while being safe for use in cattle.