Alfaxalone

Alfaxalone is a anesthetic used for inducing and maintaining anesthesia in animals. It is a neuroactive steroid with general anesthetic properties. Read more

Alfaxalone is a anesthetic used for inducing and maintaining anesthesia in animals. It is a neuroactive steroid with general anesthetic properties.

Essential insights

• GABA-A receptor modulation: Alfaxalone primarily works by modulating gamma-aminobutyric acid type A (GABA-A) receptors in the central nervous system.
• Enhancement of inhibitory neurotransmission: By binding to GABA-A receptors, alfaxalone enhances the inhibitory effects of GABA, a neurotransmitter that suppresses neuronal activity.
• Induction of anesthesia: This increased inhibition leads to a depressant effect on the central nervous system, resulting in loss of consciousness and induction of anesthesia.