Apravet

Administration route:

To be administered via the drinking water. Drinking systems should be clean and free of rust to avoid reduction of activity.

In the case of calves it can be administered in milk or milk replacer.

Amounts to be administered:

Pigs:

Administer 12,500 IU apramycin sulfate per kilogram of bodyweight (corresponding to 22.5 mg of product/kg bw), daily for 7 consecutive days.

Calves:

Administer 40,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 72 mg of product/kg bw), daily for 5 consecutive days.

Chickens:

Administer 80,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 144 mg of product/kg bw), daily for 5 consecutive days.

Rabbits:

Administer 20,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to 36 mg of product/kg bw), daily for 5 consecutive days.

The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dose, the concentration of the veterinary medicinal product has to be adjusted accordingly.

The amount of product (mg) to be incorporated per 1 l of water or milk should be established according to the following formula:

Dose (mg product per kg mean body weight (kg)

X

body weight per of animals to be treated mg product per litre of ^{day) =} drinking water/milk

Average daily water intake (l/animal)

To ensure a correct dosage, bodyweight should be determined as accurately as possible to avoid under-dosing. Prepare the solution with fresh tap water (or milk/milk replacer for calves) immediately before use. Medicated drinking water should be refreshed or replaced every 24 hours. Milk replacer should be prepared prior to the addition of the powder. The solution should be vigorously stirred for 5 minutes. Medicated milk/milk replacer should be consumed immediately after preparation Water uptake should be monitored at frequent intervals during medication. In order to ensure consumption of the medicated water, animals should not have access to other water supplies whilst being treated. After the end of the medication period, the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance. If it is not possible to obtain sufficient uptake of medicated water, animals should be treated parenterally (where appropriate). The maximum solubility of the product in water and milk replacer is approximately 1000 g/L. The use of suitably calibrated weighing equipment is recommended to ensure accurate measurement of the amount of product to be administered.