Reprocine

1 x 50 ml

Solution for injection

Active substance

Carbetocin : 0,07 mg/ml

ATC code

QH01BB03 Carbetocin

QH01BB Oxytocin and analogues

QH01B Posterior pituitary lobe hormones

QH01 Pituitary, hypothalamic hormones and analogues

QH Systemic hormonal preparations, excl. sex hormones and insulins

Species

Cattle, pig

Indications

Cow:

- Uterine atony during the puerperal period,

- Placental retention as a consequence of uterine atony

- Initiation of milk ejection in stress-induced agalactia or in conditions requiring udder emptying

Sow:

- Uterine atony during the puerperal period

- Supportive therapy of mastitis-metritis-agalactia (MMA-) syndrome

- Initiation of milk ejection

- Shortening of total parturition duration in sows: either after delivery of the first piglet or as a component of synchronisation of parturition in sows, which have not farrowed 24 hours after administration of an appropriate PGF_2α (e.g. cloprostenol) not before day 113 of pregnancy.

Dose to be administered and administration route

Cows

For all indications: 3.0 – 5.0 ml/animal, corresponding to 0.21 – 0.35 mg carbetocin/animal

Sows

For uterine atony, MMA and milk ejection:

1.5 – 3.0 ml/animal, corresponding to 0.105 – 0.21 mg carbetocin/animal

For shortening of total parturition duration as a part of the synchronisation of parturition:

1.0 ml/animal, corresponding to 0.07 mg carbetocin/animal

The dosage requirements can be variable within the indicated limits based on the assessment of the veterinarian.

For single intramuscular or intravenous injection.

In case of treatment for milk ejection in the cow and sow or supportive therapy in MMA-syndrome in sow, a repeated administration is possible after 1 to 2 days.

Special information:

The responsiveness to carbetocin of the myometrium is likely to be close to zero from the 5^th to the 11^th day post partum. Therefore, the administration of the veterinary medicinal product during this period is likely to be inefficient and should be avoided.

If treatment with carbetocin should fail, then it is advisable to reconsider the aetiology of the condition, specifically if hypocalcaemia could be a complicating factor.

In case of severe septic metritis, appropriate concomitant therapy should be instigated when administering the veterinary medicinal product.