Bovilis Rotavec Corona vet.
Active substance
ATC code
Species
Cattle (pregnant cows and heifers).
Indications
For the active immunisation of pregnant cows and heifers to raise antibodies against
E. coli adhesins F5 (K99) and F41, rotavirus and coronavirus. While calves are fed colostrum from vaccinated cows during the first two to four weeks of life, these antibodies have been demonstrated to:
- reduce the severity of diarrhoea caused by E. coli F5(K99) and F41
- reduce the incidence of scours caused by rotavirus
- reduce the shedding of virus by calves infected with rotavirus or coronavirus.
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Onset of Immunity: |
Passive protection against all active substances will commence from the start of colostrum feeding. |
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Duration of Immunity:
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In calves artificially fed with pooled colostrum, protection will continue until colostrum feeding ceases. In naturally suckled calves, protection against rotavirus will persist for at least 7 days and against coronavirus for at least 14 days. |
Dose to be administered and administration route
Intramuscular use.
Shake well before use. Syringes and needles should be sterilised before use and the injection should be made through an area of clean, dry skin taking precautions against contamination.
Strict precautions should be taken against contamination of the vaccine. The use of a multi-dose syringe is recommended to avoid excessive broaching of the stopper. Once a vial is broached for the first time it may be used once more during the next 28 days and then discarded immediately after that use.
Administration:
Administer a single dose of 2 ml per animal. The recommended site of injection is the side of the neck.
A single injection should be given during each pregnancy between 12 and 3 weeks before calving is expected.
Colostrum feeding:
Protection of calves depends on the physical presence of colostrum antibodies (from vaccinated cows) within the gut for the duration of the first 2 - 3 weeks of life until calves develop their own immunity. Thus, it is essential to ensure adequate colostrum feeding for the whole of this period to maximise the efficacy of vaccination.
All calves must receive adequate colostrum from their dams within 6 hours of birth.
Suckled calves will continue to receive adequate colostrum naturally by feeding from vaccinated cows.
In the dairy herd colostrum/milk from the first 6 - 8 milkings of vaccinated cows should be pooled. The colostrum may be stored below 20 °C, but should be used as soon as possible as immunoglobulin levels may fall by up to 50% after storage for 28 days. Where possible, storage at 4 °C is recommended. The calves should be fed on this pool at the rate of 2½ to 3½ litres per day (according to body size) for the first two weeks of life.
Optimal results will be obtained if a whole herd cow vaccination policy is adopted. This will ensure that in calves the level of infection and consequent virus excretion is kept to a minimum and consequently the overall level of disease challenge on the farm is minimised.
Adverse reactions
A soft swelling raised up to 1 cm was observed very commonly at the site of injection during safety and clinical studies. These swellings usually resorb within 14 to 21 days.
Hypersensitivity reactions were observed in spontaneous pharmacovigilance reports in very rare cases. In such cases, appropriate treatment such as adrenaline should be administered without delay.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
