Clynav

1 x 250 ml

Liquid for injection, solution

Active substance

Salmon pancreas disease virus (SPDV) (pUK-SPDV-poly2#1 DNA plasmid)

ATC code

QI10AX Other immunologicals

QI10A Immunologicals for atlantic salmon

QI10 Immunologicals for pisces

QI Immunologicals

Species

Atlantic salmon (Salmo salar).

Indications

For the active immunisation of Atlantic salmon to reduce impaired daily weight gain, and reduce mortality, and cardiac, pancreatic and skeletal muscle lesions caused by pancreas disease following infection with salmonid alphavirus subtype 3 (SAV3).

Onset of immunity occurs within 399 degree days (mean water temperature in °C multiplied by number of holding days) following vaccination.

Duration of immunity: 1 year for reduction in impaired daily weight gain, and cardiac, pancreatic and skeletal muscle lesions and 9.5 months for reduction of mortality (demonstrated in a laboratory efficacy study in saltwater conditions using a cohabitation challenge model).

Dose to be administered and administration route

Intramuscular use.

Shake product gently before use.

Transfer tubing kit instructions: using the spiked end, screw the transfer tubing set onto the fill port of the ethyl vinyl acetate (EVA) bag with a ¼ turn in order to secure the line in place. Connect the other end of the transfer tubing set to the vaccine injection equipment (gun).

Anaesthetise the fish to immobilise them and administer 0.05 ml of the vaccine by intramuscular injection in the epaxial muscle. Position the needle at 90° in the epaxial muscle, in the area immediately anterior and lateral to the dorsal fin, along a line equidistant to the dorsal fin and the mid-line, and at the point of the muscle’s maximum girth.

Based on a 25 g fish weight a standard 0.5 mm diameter 3mm depth needle is recommended to be used routinely. Consideration should be made for the weight of the fish before the final selection is made. Injection equipment should be calibrated and inspected regularly to ensure appropriate dosing of the fish.

Adverse reactions

Atlantic salmon:

Very common

(>1 animal / 10 animals treated):

Abnormal swimming in fish^¹

Fish colour change^², Inappetence^³

Common

(1 to 10 animals / 100 animals treated):

Puncture wound^⁴

¹ for up to two days.

² for up to seven days.

³ for up to nine days.

⁴ Needle injuries can persist in up to 5% of fish for at least 90 days and can be seen both macroscopically and microscopically.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See also the last section of the package leaflet for contact details.