Moxisolv LA
Active substance
ATC code
Species
Cattle
Indications
In cattle weighing from 100 to 500 kg body weight, treatment and prevention of mixed infestations by the following gastro-intestinal nematodes, respiratory nematodes and certain arthropod parasites:
Adult and immature gastro-intestinal nematodes:
Haemonchus placei
Haemonchus contortus
Ostertagia ostertagi (including inhibited larvae)
Trichostrongylus axei
Trichostrongylus colubriformis
Nematodirus helvetianus (adults only)
Nematodirus spathiger
Cooperia surnabada
Cooperia oncophora
Cooperia pectinata
Cooperia punctata
Oesophagostomum radiatum
Bunostomum phlebotomum (adults only)
Chabertia ovina (adults only) Trichuris spp. (adults only)
Adult and immature respiratory tract nematode: Dictyocaulus viviparus
Warble grubs (migrating larvae):
Hypoderma bovis Hypoderma lineatum
Lice:
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Bovicola bovis (reduction of infestation)
Mange mites:
Sarcoptes scabiei
Psoroptes ovis
Chorioptes bovis (reduction of infestation)
Moxidectin has a persistent action and protects cattle for a certain duration against infection or re-infection with the following parasites for the period indicated:
|
Species: |
Protection period (days): |
|
Dictyocaulus viviparus |
120 |
|
Ostertagia ostertagi |
120 |
|
Haemonchus placei |
90 |
|
Oesophagostomum radiatum |
150 |
|
Trichostrongylus axei |
90 |
|
Linognathus vituli |
133 |
The veterinary medicinal product is effective against Hypoderma larvae at the time of treatment but its persistent activity against Hypoderma has not been evaluated. If the veterinary medicinal product is given before the end of the fly season complimentary treatment with a product effective against Hypoderma may be required.
Persistent efficacy periods have not been established for parasite species other than those included in the above list. Therefore, re-infection of animals on pasture contaminated by parasites other than these remains possible before the end of the 90-day minimum persistency period demonstrated for specific species.
Dose to be administered and administration route
Subcutaneous use.
Dosage is 1.0 mg moxidectin per kg bodyweight (equivalent to 0.5 ml of the veterinary medicinal product per 50 kg bodyweight), given by a single subcutaneous injection in the ear using an 18 gauge, 25 – 40 mm hypodermic needle. The 50 ml vial stoppers must not be broached more than 30 times, and the 200 ml vial stoppers must not be punctured more than 50 times. Use automatic syringe equipment for the 200 ml fill size.
Shake well before use.
Underdosing could result in ineffective use and may favour resistance development. To ensure a correct dosage, body weight should be determined as accurately as possible. If animals are to be treated collectively, reasonably homogenous groups should be set up, and all animals of a group should be dosed at the rate corresponding to the heaviest one.
Accuracy of the dosing device should be thoroughly checked.
The injection should be given subcutaneously in the loose tissues on the dorsal surface of the ear, just distal to the distal edge of the auricular cartilage. The dorsal (outer) surface of the ear should first be cleansed with antiseptic and allowed to briefly air dry. Palpate the edge of the auricular cartilage closest to the head, on the dorsal (hairy) surface of the ear. From this landmark, taking care to avoid blood vessels (artery, vein), the needle should be inserted subcutaneously starting at a point approximately 3 to 3.5 cm distal to this edge (away from the head), and directed towards the base of the ear, and the needle advanced to the hub. At this point, gently aspirate the syringe to confirm that the needle is not in a blood vessel. Upon injection, the resulting depot should reside just distal to the edge of the auricular cartilage.
Following administration, the needle is withdrawn from the skin as pressure is applied for several seconds with the thumb at the point of insertion.
Due to the long lasting protection against Dictyocaulus viviparus and the stomach worms, Ostertagia ostertagi and Haemonchus placei, a single treatment with the formulation at turn-out helps control parasitic bronchitis (lungworm) and parasitic gastro-enteritis throughout the grazing season by reducing the build-up of infective larvae on pasture associated with these parasites.
Diagram: Ear injection procedure
• 
The injection site is approximately 3.5 cm (1.5 inches) distal to the distal edge of the auricular cartilage
• Use one hand to grasp and steady the ear.
• Inject subcutaneously using an 18gauge x 1inch needle.
• Inject contents. Depot should be just distal to the distal edge of the auricular cartilage.
• Apply pressure at the point of insertion as the needle is withdrawn from the skin to help seal the opening.
Adverse reactions
Immediate or delayed swelling can be observed at the injection site on rare occasions. These swellings may further develop into abscesses (approx. 1% of cases). The frequency of injection site swellings tends to be higher in the heavier animals. These side effects generally disappear without treatment, within 14 days after administration, some may persist for up to 5 weeks in a number of animals (<5%) and in very rare occasions longer.
Depression and ataxia can be observed on rare occasions after injection.
In case of hypersensitivity reactions, a symptomatic treatment should be applied.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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|---|---|
| Art. Nr. | 50146/5001 |
| EAN | 5391510239123 |
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