Advocin 180

1 x 50 ml

Liquid for injection, solution

Active substance

Danofloxacin (Danofloxacin-mesilate) : 180 mg/ml

ATC code

QJ01MA92 Danofloxacin

QJ01MA Fluoroquinolones

QJ01M Quinolone and quinoxaline antibacterials

QJ01 Antibacterials for systemic use

QJ Antiinfectives for systemic use

Species

Cattle.

Indications

In cattle:

Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to danofloxacin.

For the treatment of acute bovine mastitis caused by Escherichia coli sensitive to danofloxacin.

In neo-natal calves:

Treatment of enteric infections caused by Escherichia coli sensitive to danofloxacin.

Dose to be administered and administration route

Intravenous or subcutaneous routes.

6 mg/kg body weight (1 ml/30 kg body weight) as a single injection.

If clinical signs of respiratory or enteric disease persist 48 hours after the first injection, an additional dose at 6 mg/kg body weight may be administered.

It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours.

For the treatment of acute bovine mastitis, the veterinary medicinal product should be administered at 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route. The clinical signs should be monitored carefully and supportive therapy should be given as appropriate. If clinical signs of acute bovine mastitis persist 36-48 hours after the first injection, the antibiotic treatment strategy should be reviewed. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 36-48 hours.

For treatment of cattle weighing more than 450 kg, divide the subcutaneous dose so that no more than 15 ml are injected at one site.

When dosing a large number of animals from a single vial, the use of an automatic syringe is recommended to avoid excessive broaching of the rubber stopper.

To ensure a correct dosage, body weight should be determined as accurately as possible.

Adverse reactions

Cattle:

Very rare

(<1 animal / 10,000 animals treated, including isolated reports):

Anaphylactic shock¹

In sensitive animals, immediate or delayed.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder <or its local representative> or the national competent authority via the national reporting system. See also ‘Contact details’ of the package leaflet.