Suvaxyn PRRS MLV
ATC code
Species
Pigs (pigs for fattening, gilts and sows)
Indications
For active immunisation of clinically healthy pigs from 1 day of age in a porcine respiratory and reproductive syndrome (PRRS) virus contaminated environment, to reduce viraemia and nasal shedding caused by infection with European strains of PRRS virus (genotype 1).
Onset of immunity: 21 days after vaccination.
Duration of immunity: 26 weeks after vaccination.
Fattening pigs:
In addition, intramuscular vaccination of seronegative 1-day-old piglets was demonstrated to reduce lung lesions against challenge administered at 26 weeks post vaccination. Intramuscular vaccination of seronegative 2-week-old piglets was demonstrated to reduce lung lesions and oral shedding against challenge administered at 28 days and at 16 weeks post-vaccination.
Additionally, nasal vaccination of seronegative 3-day-old piglets reduced viraemia, nasal shedding and lung lesions against challenge administered at 21 days postvaccination. Nasal vaccination of seropositive 3-day-old piglets reduced viraemia, nasal shedding and lung lesions against challenge administered 10 weeks postvaccination.
Gilts and sows:
In addition, pre-pregnancy vaccination of clinically healthy gilts and sows, non-PRRS virus-naïve (i.e. either previously immunised against PRRS virus via vaccination or exposed to PRRS virus via field infection) or PRRS virus-naïve, was demonstrated to reduce the transplacental infection caused by PRRS virus during the last third of pregnancy, and to reduce the associated negative impact on reproductive performance (reduction of the occurrence of stillbirths, of piglet viraemia at birth and at weaning, of lung lesions and of viral load in lungs in piglets at weaning).
Dose to be administered and administration route
Method of administration:
Immunisation must be carried out by intramuscular or nasal administration.
Reconstitute the lyophilisate with the supplied solvent. In cases where the vials containing the solvent and the lyophilisate are stored separately, verify prior to reconstituting the lyophilisate that the lot number mentioned on the vial containing the solvent is identical to the lot number mentioned on the vial containing the lyophilisate. Transfer approximately 5 ml of solvent to the vial containing the lyophilisate and ensure complete reconstitution. Transfer back the reconstituted solution into the solvent vial (containing the remaining solvent): 25 doses are reconstituted into 50 ml solvent, 50 doses are reconstituted into 100 ml solvent, and 125 doses are reconstituted into 250 ml solvent.
Dosage:
Intramuscular injection: 2 ml in the neck.
Nasal administration: 2 ml administered as 1 ml in each nostril.
Vaccination schedule:
Pigs for fattening from 1 day of age onwards:
A single dose of 2 ml is given to pigs via intramuscular administration.
Pigs for fattening from 3 days of age onwards:
A single dose of 2 ml is given to pigs via intramuscular administration, or a single dose of 2 ml is given to pigs via nasal route by administering 1 ml in each nostril using a sterile syringe not connected to a needle.
Gilts and sows: A single dose of 2 ml is given intramuscularly prior to introduction into the sow herd, approximately 4 weeks prior to breeding. A single booster dose is given every 6 months.
Use sterile syringes and needles.
The use of a multi-dosing syringe is recommended. Use vaccination devices according to the manufacturer’s instructions. Needles for administration should be appropriate for the size of the pig.
Adverse reactions
A transient increase in rectal temperature (0.5 °C on average, and up to 1.4 °C individually) may very commonly occur within 4 days after vaccination. Local reactions in the form of swellings are common and resolve spontaneously within 3 days. The area of local tissue reaction is in general below 2 cm in diameter. Anaphylactic-type reactions (vomiting, tremors and/or mild depression) may uncommonly occur in piglets shortly after vaccination. These resolve without treatment within few hours.
A minor and transient increase in rectal temperature (0.2 °C on average, and up to 1.0 °C individually) may very commonly occur 4 hours post vaccination in prebreeding PRRS virus-naïve gilts and sows. Local reactions in the form of swellings are very common and resolve spontaneously within 5 days. The area of local tissue reaction is in general below 0.5 cm in diameter.
A minor and transient increase in rectal temperature (0.8 °C on average, and up to 1.0 °C individually) may very commonly occur 4 hours post vaccination in PRRS virus-naïve gilts and sows in the first half of gestation. Local reactions in the form of swellings are very common and resolve spontaneously within 9 days. The area of local tissue reaction is in general below 1.4 cm in diameter.
A minor and transient increase in rectal temperature (0.4 °C on average, and up to 0.6 °C individually) may very commonly occur 4 hours post vaccination in non-PRRS virus-naïve gilts and sows in the second half of gestation. Local reactions in the form of swellings are very common and resolve spontaneously within 32 days. The area of local tissue reaction is in general below 5 cm in diameter.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
