Cerenia
Active substance
ATC code
Species
Dogs.
Indications
• For the prevention of nausea induced by chemotherapy.
• For the prevention of vomiting induced by motion sickness.
• For the prevention and treatment of vomiting, in conjunction with Cerenia solution for injection and in combination with other supportive measures.
Dose to be administered and administration route
For oral use.
For motion sickness, a light meal or snack before dosing is recommended; prolonged fasting before administration should be avoided. However, Cerenia tablets should not be administered wrapped or encapsulated in food as this may delay dissolution of the tablet and consequently the onset of efficacy.
Dogs should be carefully observed following administration to ensure that each tablet is swallowed.
For the prevention of nausea induced by chemotherapy and treatment and prevention of vomiting (except motion sickness), (only for dogs 8 weeks of age or older).
To treat or prevent vomiting, Cerenia tablets should be administered once daily, at a dose of 2 mg maropitant per kg bodyweight, using the number of tablets given in the table below. Tablets are breakable along the score line on the tablet.
To prevent vomiting, tablets should be given more than 1 hour in advance. The duration of the effect is approximately 24 hours and, therefore, tablets can be given the night before administration of an agent that may cause emesis (e.g. chemotherapy).
Cerenia can be used to treat or prevent vomiting either as tablets or as solution for injection administered once daily. Cerenia solution for injection may be administered for up to five days and Cerenia tablets for up to fourteen days.
Prevention of nausea induced by chemotherapy Treatment and prevention of vomiting (except motion sickness) | |
Dog body weight (kg) | Number of tablets |
24 mg | |
8.1–12.0 | 1 |
12.1–24.0 | 2 |
To prevent vomiting induced by motion sickness, Cerenia tablets should be administered once daily, at a dose of 8 mg maropitant per kg bodyweight, using the numbers of tablets given in the table below. Tablets are breakable along the score line on the tablet.
Tablets should be administered at least one hour before starting the journey. The anti-emetic effect persists for at least 12 hours, which for convenience may allow administration the night before early morning travel. Treatment may be repeated for a maximum of two consecutive days.
Prevention of motion sickness | |
Dog body weight (kg) | Number of tablets |
24 mg | |
1.0–1.5 | ½ |
2.1–3.0 | 1 |
4.1–6.0 | 2 |
As the pharmacokinetic variation is large and maropitant accumulates in the body after once daily repeated administration, lower doses than recommended might be sufficient in some individuals and when repeating the dose.
Adverse reactions
Dogs:
|
Common (1 to 10 animals / 100 animals treated): |
Vomiting1 |
|
Very rare (<1 animal / 10,000 animals treated, including isolated reports): |
Neurological disorder (e.g. ataxia, convulsion, seizure, muscle tremor) Lethargy |
1 Observed pre-travel, usually within two hours of dosing.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See also section “Contact details” of the package leaflet.
TRUSTED SOURCE
