Cerenia
Active substance
ATC code
Species
Dogs and cats.
Indications
• For the treatment and prevention of nausea induced by chemotherapy.
• For the prevention of vomiting except that induced by motion sickness.
• For the treatment of vomiting, in combination with other supportive measures.
• For the prevention of perioperative nausea and vomiting and improvement in recovery from general anaesthesia after use of the μ-opiate receptor agonist morphine.
Cats• For the prevention of vomiting and the reduction of nausea, except that induced by motion sickness.
• For the treatment of vomiting, in combination with other supportive measures.
Dose to be administered and administration route
For subcutaneous or intravenous use in dogs and cats.
Cerenia solution for injection should be injected subcutaneously or intravenously, once daily, at a dose of 1 mg/kg bodyweight (1 ml/10 kg bodyweight) for up to 5 consecutive days. Intravenous administration of Cerenia should be given as a single bolus without mixing the product with any other fluids.
In dogs, Cerenia can be used to treat or prevent vomiting either as tablets or as solution for injection administered once daily. Cerenia solution for injection may be administered for up to five days and Cerenia tablets for up to fourteen days.
To prevent vomiting, Cerenia solution for injection should be administered more than 1 hour in advance. The effect duration is approximately 24 h and therefore treatment can be given the night before administration of an agent that may cause emesis e.g. chemotherapy.
As the pharmacokinetic variation is large and maropitant accumulates in the body after once daily repeated administration, lower doses than recommended might be sufficient in some individuals and when repeating the dose.
Adverse reactions
Dogs and cats:
Very common (>1 animal / 10 animals treated): |
Injection site pain1,2 |
Very rare (<1 animal / 10,000 animals treated, including isolated reports): |
Anaphylactic-type reaction (e.g. allergic oedema, urticaria, erythema, collapse NOS, dyspnoea, pale mucous membranes) Lethargy Neurological disorder (e.g. ataxia, convulsion, seizure, muscle tremor) |
1 When injected subcutaneously.
2 A moderate to severe response can be observed in approximately one third of cats.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See also section 16 of the package leaflet for respective contact details.