Synulox
Active substance
ATC code
Species
Dogs.
Indications
In vitro the product is active against a wide range of clinically important aerobic and anaerobic bacteria, including:
Gram-positive: Staphylococci (including β-lactamase-producing strains) Clostridia; Actinomyces; Peptostreptococcus spp; Streptococci; Enterococci.
Gram-negative: Bacteroides spp. (including β-lactamase-producing strains); Escherichia coli (including β-lactamase-producing strains); Salmonellae (including β-lactamase-producing strains); Bordetella bronchiseptia; Campylobacter spp; Fusobacterium necrophorum; Klebsiellae; Pasteurellae; Proteus spp.
Clinically, amoxicillin has been shown to be effective in treating a wide range of diseases of dogs including: skin disease (including deep and superficial pyoderma); urinary tract infection; respiratory disease involving upper and lower respiratory tract; enteritis; dental infections (e.g. gingivitis); soft tissue infections (e.g. abscesses and anal sacculitis).
Note: The product is not indicated for cases involving Pseudomonas spp.
Dose to be administered and administration route
Dosage Rate:
Recommended dose rate is 12.5 mg/kg, twice daily.
Dosage guide:
For oral administration only. The tablets are often accepted from the hand, even by sick dogs. Alternatively, the tablets may be crushed and added to a small quantity of food.
The majority of routine cases will respond to between 5 and 7 days therapy. Because of the low toxicity profile, the dose can be doubled if desired in refractory cases.
In certain indications, for example canine pyoderma and chronic cystitis, bacterial infection may be secondary to other pathology. For such cases long courses of antibacterial therapy may be required, in addition to diagnosis and treatment of the underlying condition. In such circumstances overall treatment length must be at the clinician’s discretion, but should be long enough to ensure complete resolution of the bacterial disease.
Adverse reactions
Very rarely hypersensitivity reactions (allergic skin reactions, anaphylaxis) may occasionally occur. If allergic reactions occur, the product should be discontinued immediately. Appropriate symptomatic treatment should be initiated.
In very rare cases the use of the product may result in instances of gastrointestinal disorders (vomiting, diarrhoea, anorexia).
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
References
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