Synulox
Active substance
ATC code
Species
Cats and dogs.
Indications
The product is indicated for the treatment of a wide range of diseases of cats and dogs including: skin diseases (including deep and superficial pyodermas); urinary tract infections; respiratory diseases (involving upper and lower respiratory tract); enteritis; soft tissue infections (abscesses and anal sacculitis); dental infections (e.g. gingivitis).
The product is effective against Klebsiella infections found in veterinary practice, but it is not indicated for cases involving Pseudomonas species.
Dose to be administered and administration route
Reconstitution: Add 15 ml water. Shake the bottle before use.
Administration: by the oral route.
Dosage rate: 12.5 mg/kg bodyweight (i.e. 0.25 ml/kg). For the accurate dosing of particularly small patients it is valuable to note that one drop from the pipette provided contains 2.3 mg clavulanate-potentiated amoxicillin. Therefore 5-6 drops/kg twice daily are recommended as a guide.
Dosage frequency: Dogs and cats should be dosed at the rate of 0.25 ml of reconstituted product per kg bodyweight twice daily.
For the majority of infections, including those of the skin, urinary tract and gastrointestinal tract, the above dosage regime is effective. Refractory cases however, particularly those of the respiratory tract, have shown improved cure rates by doubling the dose to 25 mg/kg bodyweight, twice daily (i.e. 0.5 ml of reconstituted product twice daily).
Duration of therapy: Routine cases involving all indications: the majority of these cases respond to between 5 and 7 days therapy.
Chronic or refractory cases: In these cases, where there is considerable tissue damage, a longer course of therapy may be required in that it allows sufficient time for damaged tissue to repair. Based on clinical trials, the following durations are suggested as guidelines:
| Chronic skin disease | 10 - 20 days |
| Chronic cystitis | 10 - 28 days |
| Respiratory disease | 8 - 10 days |
Adverse reactions
In very rare cases the use of the product may result in occasional instances of gastro-intestinal disorders (vomiting, diarrhoea, anorexia).
In very rare cases hypersensitivity (allergy, allergic skin reactions) may occur after use. Allergic reactions may occasionally be serious (anaphylaxis). If allergic reactions occur, the product should be discontinued immediately. Appropriate symptomatic treatment should be initiated.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
