Excenel
Active substance
ATC code
Species
Cattle, pigs and horses.
Indications
Ceftiofur sodium (Excenel) is indicated for treatment of bovine bacterial respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, and Actinobacillus (Haemophilus) somnus and other sensitive bacterial pathogens.
For the treatment of cattle with acute interdigital necrobacillosis (foul in the foot) in which Fuosbacterium necrophorum and Bacteroides melaninogenicus are involved.
The treatment of pigs with bacterial respiratory disease in which Actinobacillus (Haemophilus) pleuropneumonia, Pasteurella multocida and Streptococcus suis are involved.
For the treatment of horses with bacterial respiratory disease associated with Streptococcus spp. (including Streptococcus zooepidemicus), Staphylococcus spp. and/or Pasteurella spp.
Dose to be administered and administration route
Dissolve the 1 g sterile powder in 20 ml of Water for Injection. Dissolve the 4 g sterile powder in 80 ml of Water for Injection
Rapid addition of diluent will give best results.
The resulting solution contains 50 mg ceftiofur free acid equivalents per ml. The reconstituted product is to be administered intramuscularly. For ease of reconstitution use an 18 gauge needle.
Dosage
Cattle:
1 mg/kg bodyweight. This is equivalent to 1 ml of the reconstituted solution per 50 kg bodyweight.
For respiratory disease, the dose should be given once daily at 24 hour intervals for 3 to 5 days in total.
For interdigital necrobacillosis (foul in the foot), the dose should be given once daily at 24 hour intervals for 3 days. As with all antibiotic therapy, treatment of this condition with Excenel should be instituted as early as possible in order to provide maximum clinical benefit.
Pigs:
3 mg/kg bodyweight: This is equivalent to 1 ml of the reconstituted solution per 16 kg bodyweight. The dose should be given once daily at 24 hour intervals for 3 days.
If no response is seen within these periods, the diagnosis should be redetermined.
Horses:
2 mg/kg bodyweight: This is equivalent to 2 ml of the solution per 50 kg bodyweight. The dose should be given once daily at 24 hour intervals and continued for 48 hours after clinical signs have disappeared. A 10-day treatment period is usually adequate. A maximum of 10 ml solution should be administered per injection site.
If no response is seen within 4-5 days, the diagnosis should be re-determined.
Administration
The intramuscular route only should be used in cattle, pigs and horses.
Adverse reactions
General symptoms are not detected. The use of ceftiofur sodium may result in some signs of immediate and short lasting pain at the site of injection.
