Excenel Flow
Active substance
ATC code
Species
Pigs and cattle.
Indications
Infections associated with bacteria sensitive to ceftiofur:
In pigs:
For the treatment of bacterial respiratory disease associated with Pasteurella multocida, Actinobacillus pleuropneumoniae and Streptococcus suis.
In cattle:
For the treatment of bacterial respiratory disease associated with Mannheimia haemolytica (former Pasteurella haemolytica), Pasteurella multocida and Histophilus somni (former Haemophilus somnus).
For the treatment of acute interdigital necrobacillosis (panaritium, foot rot), associated with Fusobacterium necrophorum and Bacteroides melaninogenicus (Porphyromonas asaccharolytica).
For treatment of the bacterial component of acute post-partum (puerperal) metritis within
10 days after calving associated with Escherichia coli, Arcanobacterium pyogenes and Fusobacterium necrophorum, sensitive to ceftiofur, were treatment with another antimicrobial has failed.
Dose to be administered and administration route
Before use, shake the bottle vigorously for a maximum of 60 seconds or until the product appears adequately resuspended.
To ensure a correct dosage, bodyweight should be determined as accurately as possible to avoid underdosing.
Pigs:
3 mg ceftiofur /kg bw/day for 3 days via intramuscular route, i.e. 1 ml/16 kg bw at each injection.
Not more than 4 ml should be administered per injection site.
Cattle:
Respiratory disease: 1 mg ceftiofur /kg bw/day for 3 to 5 days by subcutaneous injection, i.e. 1 ml/50 kg bw at each injection.
Acute interdigital necrobacillosis: 1 mg/kg bw/day for 3 days by subcutaneous injection, i.e.
1 ml/50 kg bw at each injection.
Acute post-partum metritis within 10 days after calving: 1 mg/kg bw/day for 5 consecutive days by subcutaneous injection, i.e. 1 ml/50 kg bw at each injection. Not more than 13 ml should be administered per injection site.
In case of acute post-partum metritis, additional supportive therapy might be required in some cases.
Subsequent injections must be given at different sites.
50 ml and 100 ml vials can be broached a maximum of 50 times. 250 ml vials can be broached a maximum of 33 times. Otherwise, the use of a multiple-dose syringe is recommended.
Adverse reactions
Hypersensitivity reactions unrelated to dose can occur. Allergic reactions (e.g. skin reactions, anaphylaxia) have been reported in very rare cases (less than 1 animal in 10,000 animals, including isolated reports).
In pigs, mild reactions at the injection site, such as discoloration of the fascia or fat, have been observed in very rare cases for up to 20 days after injection.
In cattle, firmness and swelling were observed at the injection site after SC injection of the test article. Mild to moderate local chronic inflammation was observed in most animals until 42 days post injection. Injection site reactions have been reported from the field in very rare cases.
References
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Excenel Flow
