Amphen
Active substance
ATC code
Species
Pigs
Indications
Treatment and metaphylaxis of swine respiratory disease associated with Actinobacillus pleuropneumoniae and Pasteurella multocida susceptible to florfenicol. The presence of the disease must be established in the group before metaphylactic treatment.
Dose to be administered and administration route
In drinking water use.
10 mg florfenicol /kg bodyweight per day in drinking water for 5 consecutive days.
The daily amount of product to be mixed with drinking water can be calculated based on the Total Body Weight (TBW) of the group to be treated with the following formula:
Amount of product (in grams) per day* | = | Total Body Weight of the group (TBW) in Kg |
20
* to be mixed with the estimated total water consumption of the group in 24 hr
The examples of medicated drinking water in the table below are calculated by applying the formula and by assuming that pigs drink 8% or 10% of their bodyweight.
TBW of the group (Kg) | Product (g) | Estimated daily water consumption (L) | Product grams per 10 litres of water | |
Pigs drinking 8% of their bodyweight | 500 kg | 25 g | 40 L | 6.25 g/10L |
1000 kg | 50 g | 80 L | ||
5000 kg | 250 g | 400 L | ||
Pigs drinking 10% of their bodyweight | 500 kg | 25 g | 50 L | 5 g/10L |
1000 kg | 50 g | 100 L | ||
5000 Kg | 250 g | 500 L |
The maximum solubility of the product granules is 2.5g/L at 10°C and 20°C and 2.0 g/L at 5°C. Dissolution may take up to 30 minutes. During dissolution the solution should be stirred for at least 5 minutes at 50 RPM.Solutions should be checked visually for complete dissolution.
FOR BULK TANK:
Any solution for use in a header tank must be limited to not more than the maximum solubility
FOR PROPORTIONER:
For stock solutions and when using a proportioner, take care not to exceed the maximum solubility which can be achieved under the given conditions. Adjust flow rate settings of the dosing pump according to concentration of the stock solution and water intake of the animals to be treated.
To treat 5,000 kg of pigs, drinking 10% of their bodyweight, at the dose rate of 10 mg/kg:
1. Fill the proportioner with 100L drinking water (temperature not below 10°C).
2. Add 250g of product to the proportioner. 3. Mix thoroughly until visually dissolved
4. Set the proportioner to 20%.
5. Turn on the proportioner.
In order to ensure correct dosing and to prevent underdosing, the body weight of the group should be calculated as precisely as possible and water consumption should be monitored. The required quantity of granules should be measured by suitably calibrated weighing equipment.
The uptake of water depends on several factors including the age, the clinical state of the animals and the local conditions such as ambient temperature and humidity. The daily water consumption can be underestimated (e.g. reduced to 6% of bodyweight) in order to ensure total consumption of medicated water during the day (fresh drinking water can be made available following the consumption of the medicated water). If it is not possible to obtain sufficient uptake of medicated water animals should be treated parenterally.
Medicated drinking water should be replaced every 24 hours.
Adverse reactions
A slight reduction of water consumption by the animals, inappetance, dark brown faeces and constipation may be observed during treatment.
Diarrhoea and/or peri-anal and rectal erythema/oedema have been observed very commonly in treated animals. These effects are transient.
Prolapse of the rectum, that resolves without treatment, has been observed very rarely in affected animals.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated )
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
References
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| Art. Nr. | |
| EAN | 5414916101013 |
