Parofor
Active substance
ATC code
Species
Cattle (pre-ruminant calves), pigs.
Indications
Treatment of gastro-intestinal infections caused by Escherichia coli.
Dose to be administered and administration route
Oral use.
Pre-ruminant cattle:
For administration in milk/milk replacer.
25-50 mg paromomycin sulfate per kg BW/day (equivalent to 0.125 – 0.25 ml of product/kg BW/day).
Duration of treatment: 3-5 days.
Pigs:
For administration in drinking water.
25-40 mg paromomycin sulfate per kg BW/day (equivalent to 0.125 – 0.2 ml of product/kg BW/day).
Duration of treatment: 3-5 days.
To ensure accurate measurement of the required volume of product, suitably calibrated measuring equipment should be used.
For administration via drinking water, milk or milk replacer, the exact daily amount of product should be calculated, based on the recommended dose, and the number and weight of the animals to be treated, according to the following formula:
ml product / kg body weight / day | x | Mean body weight (kg) of animals to be treated | = | .... ml product per liter drinking water /milk/milk replacer |
Mean daily water/milk/milk replacer consumption (litre) per animal |
To ensure a correct dosage body weight should be determined as accurately as possible.
The uptake of medicated water/milk /milk replacer depends on several factors including clinical conditions of the animals and the local conditions such as ambient temperature and humidity. In order to obtain the correct dosage, drinking water/milk/milk replacer uptake has to be monitored and the concentration of paromomycin has to be adjusted accordingly.
Medicated drinking water/milk/milk replacer and any stock solutions should be freshly prepared by carefully mixing the product in the requisite quantity of fresh potable water /milk/milk replacer every 6 hours (in milk/milk replacer) or every 24 hours (in water).
Adverse reactions
On rare occasions soft faeces have been observed.
Aminoglycoside antibiotics such as paromomycin can cause oto- and nephrotoxicity.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
References
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