Doxx-Sol

To be administered orally through the milk-replacer and/or the drinking water.

Cattle (Pre-ruminant calves):

for use in milk replacer

10 mg doxycycline hyclate (corresponding to 20 mg of product) /kg body weight / day, divided over 2 administrations, for 3-5 consecutive days.

Pigs:

for use in drinking water

10 mg doxycycline hyclate (corresponding to 20 mg of product) /kg body weight / day, / kg body weight/day, for 3-5 consecutive days.

Chickens (broilers, breeders, replacement pullets):

for use in drinking water

25 mg doxycycline hyclate (corresponding to 50mg of product) /kg body weight / day, / kg body weight/day, for 3-5 consecutive days.

For the administration through the drinking water, the exact daily amount of product should be calculated, based on the recommended dose, and the number and weight of the animals to be treated, according to the following formula:

To ensure a correct dosage body weight should be determined as accurately as possible.

The uptake of medicated water is dependent on the clinical conditions of the animals. In order to obtain the correct dosage, the concentration in drinking water may have to be adjusted.

The use of suitably calibrated weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water should be freshly prepared every 24 hours. It is recommended to prepare a concentrated pre-solution - not exceeding 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required. Alternatively, the concentrated solution can be used in a proportional water medicator. The water should be stirred until full dissolution of the product is obtained.

Milk replacer: The veterinary medicinal product must first be dissolved in water before adding the milk powder. The medicated milk replacer should be used immediately and should be freshly prepared after 4hours at the latest.

Sufficient access to the system of water supply should be available for the animals to be treated to ensure adequate water consumption. No other source of drinking water should be available during the medication period. At the end of treatment period the water supply should be cleaned adequately to avoid the uptake of remaining quantities in sub-therapeutic doses.

The solubility of doxycycline decreases at higher pH. Therefore, the product should not be used in hard alkaline water since precipitation might occur depending on the product concentration. Delayed precipitation might also occur.