Piglets: For the passive protection of neonatal piglets by means of the active immunisation of breeding sows and gilts to reduce mortality and clinical signs of neonatal enterotoxicosis, such as diarrhoea caused by enterotoxigenic Escherichia coli, which express F4ab (K88ab), F4ac (K88ac), F5 (K99) or F6 (987P) adhesins.

The persistence of these antibodies has not been established.

For the passive immunisation of neonatal piglets against Necrotic Enteritis by means of the active immunisation of breeding sows and gilts to induce seroneutralising antibodies against the β-toxin of Clostridium perfringens type C.

The persistence of antibodies has not been established.

Sows and gilts: For active immunisation of breeding sows and gilts to induce seroneutralising antibodies against α-toxin of Clostridium novyi type B. The relevance of the seroneutralising antibodies was not experimentally determined.

Antibodies have been detected 3 weeks after the completion of the basic vaccination scheme. The persistence of these antibodies has not been established.

Dose to be administered and administration route

Intramuscular, into the neck muscles. Dose: 2 ml/animal.

The basic vaccination scheme consists of two doses: the first dose at approximately 6 weeks before farrowing and a second dose at approximately 3 weeks before farrowing.

It is recommended that the second dose should be given preferably on alternate sides.

Revaccination: on each subsequent gestation, administer one dose 3 weeks before the expected date of farrowing.

It is advisable to administer the vaccine at a temperature between +15 ºC and +25 ºC. Shake before use.

To ensure the correct mixing with Suiseng Diff/A, the same volumes of Suiseng Diff/A and Suiseng Coli/C should be used. All the contents of Suiseng Coli/C should be transferred into a headspace bottle of Suiseng Diff/A (50 ml bottle with 10 doses, 100 ml bottle with 25 doses and 250 ml bottle with 50 doses).

A pre-sterilised transfer needle can be used according to the following instructions:

- Peel the cap of the bottle containing the vaccine Suiseng Coli/C.

- Connect one end of the transfer needle to the bottle of Suiseng Coli/C.

- Peel the cap of the headspace bottle containing the vaccine Suiseng Diff/A.

- Connect the opposite end of the transfer needle to the bottle of Suiseng Diff/A.

- Transfer all the contents of Suiseng Coli/C into the bottle of Suiseng Diff/A. - Once finished, separate both bottles and discard the needle transfer.

Shake well before use. Administer one single dose of 4 ml of the mixed vaccines.

Adverse reactions

Very rare: A small granuloma may occur in the muscle tissue at the injection site.

Uncommon: Injection site nodules can be observed, which disappear within 2-3 weeks.

Common: Temperature increase observed at 6 hours post-vaccination (mean 0.4 ºC, in individual pigs up to 1.2 ºC, uncommonly up to 2 ºC) subsiding without treatment within 24 hours post-vaccination. Palpable inflammatory local reaction (swelling, not more than 2 cm²) which resolves without treatment within 5 days post-vaccination.

The frequency of adverse reactions is defined using the following convention:

- very common (more than 1 in 10 animals treated displaying adverse reaction(s))

- common (more than 1 but less than 10 animals in 100 animals treated)

- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)

- rare (more than 1 but less than 10 animals in 10,000 animals treated)

- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).