Soludox

Administer orally in the drinking water.

Dosage: 25 mg doxycycline corresponding to 29 mg doxycycline hyclate per kg of body weight daily (equivalent to 58 mg product per kg of body weight), administered in the drinking water for 5 consecutive days.

The product should be administered continuously in the drinking water during the whole period of treatment. Based on the dosage to be used, and the number and weight of the birds to be treated, the exact daily amount of product required can be calculated.

The following formula can be used to calculate the concentration of the product in drinking water:

58 mg product / kg body weight / day	x	mean body weight (kg)  of birds to be treated	=	.... mg product per l drinking water
mean daily water consumption (l) per bird

To ensure a correct dosage, body weight should be determined as accurately as possible. The uptake of medicated drinking water depends on the clinical condition of the birds. In order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly. The use of suitably calibrated weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such that all medication will be consumed within 24 hours. Medicated drinking water should be refreshed or replaced every 24 hours. It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required.

Alternatively, the concentrated solution can be used in a proportional water medicator. Solubility of the product is pH-dependent and it may precipitate out if it is mixed in hard alkaline drinking water. Use at minimum concentrations of 200 mg powder per litre drinking water in areas with hard alkaline drinking water (hardness above 10.2°d and pH more than 8.1). During the treatment period birds should not have access to water sources other than the medicated water.