Soludox

1 x 1000 g

Oral powder

Active substance

Doxycycline (Doxycycline hyclate) : 500 mg/g

ATC code

QJ01AA02 Doxycycline

QJ01AA Tetracyclines

QJ01A Tetracyclines

QJ01 Antibacterials for systemic use

QJ Antiinfectives for systemic use

Species

Pigs and chickens (broiler, pullet, breeder).

Indications

Pigs: For the treatment of the clinical signs associated with porcine respiratory disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae susceptible to doxycycline.

Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, clinical signs and to reduce lesions due to Pasteurellosis caused by Pasteurella multocida, or to reduce morbidity and lesions due to respiratory infections caused by Ornithobacterium rhinotracheale (ORT).

Dose to be administered and administration route

Administration orally with the drinking water.

The recommended dose in pigs is:

12.5 mg doxycycline hyclate (25 mg product) per kg body weight per day for 4 consecutive days. If no improvement in clinical signs is seen within this time, the diagnosis should be reviewed and treatment changed. In case of severe infections the medication period may be prolonged for a maximum of 8 consecutive days as determined by the attending veterinary surgeon.

The recommended dose in chickens is:

10 mg doxycycline hyclate (20 mg product) per kg body weight per day for 3-4 consecutive days in case of infections caused by P. multocida and

20 mg doxycycline hyclate (40 mg product) per kg body weight per day for 3-4 consecutive days in case of infections caused by O. rhinotracheale.

Based on the dose to be used, and the number and weight of the animals to be treated, the daily amount of product required can be calculated. The following formula can be used to calculate the concentration of the product required in drinking water:

To ensure a correct dosage body weight should be determined as accurately as possible. The uptake of medicated drinking water depends on the clinical condition of the pigs/chickens. In order to obtain the correct dosage the concentration of doxycycline has to be adjusted accordingly. The use of suitably calibrated weighing equipment is recommended if part packs are used. The daily amount of product required is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated drinking water should be refreshed or replaced every 24 hours. It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required. Alternatively, the concentrated solution can be used in a proportional water medicator. Solubility of the product is pH dependent and it may precipitate out if it is mixed in hard alkaline drinking water. Use at minimum concentrations of 200 mg powder per litre drinking water in areas with hard alkaline drinking water (hardness above 10.2 °d and pH more than 8.1). During the treatment period animals should not have access to water sources other than the medicated water.

Adverse reactions

Tetracyclines may - in very rare cases - induce photosensitivity and allergic reactions. If suspected adverse reactions occur, treatment should be discontinued.

Inform your veterinary surgeon if adverse reactions occur that are not stated.